Original Article

Upregulation of Extracellular Matrix Genes Corroborates Clinical Efcacy of Human Fibroblast-Derived Growth Factors in Skin Rejuvenation

Kadoya, K. et al.

Skin care products may use various active ingredients to support skin rejuvenation including growth factors and other molecules that help to regenerate extracellular matrix (ECM) and promote skin repair. The biological effect of skin care products.......

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Original Article

Lawrence Transfer Factor: Transference of Specifc Immune Memory by Dialyzable Leukocyte Extract from a CD8+ T Cell Line

Wang, J.F. et al.

Lawrence transfer factor (TF) is defned as dialyzable leukocyte extract (DLE) that can transfer antigen-specifc cell-mediated immunity from a person testing positive for the antigen in a delayed type hypersensitivity skin test manner to a person n.......

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Original Article

The Latest Drugs and Small Molecule Inhibitors for Skin and Hair

Kalhan, Varun

Biologic drugs, a novel class of agents engineered to target specifc mediators of infammation, and small-molecule inhibitors that pen-etrate the cell membrane to interact with targets inside a cell represent the cutting-edge of pharmacological bio.......

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Original Article

A Novel Multifactorial Approach to Developing Mild Laundry Detergents and Assessing Their Relative Mildnes

Fowler, J.F. et al.

INTRODUCTION: Dermatologists are becoming more aware of the irritant and allergic potential of laundry detergents that incorporate harsh surfactants and potentially sensitizing ingredients. It is difficult however for the physician to distinguish .......

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Original Article

Real-World Clinical Experience With Apremilast in a Large US Retrospective Cohort Study of Patients With Moderate to Severe Plaque Psoriasis

Armstrong, A. et al.

OBJECTIVE: To examine real-world use and patient outcomes with apremilast, an oral PDE4 inhibitor, in the dermatology practice set-ting for treatment of patients with moderate to severe plaque psoriasis.

METHODS: This retrospective, mul.......

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Original Article

Cost Per Additional Responder Associated With Ixekizumab and Etanercept in the Treatment of Moderate-to-Severe Psoriasis

Feldman, S.R. et al.

BACKGROUND: Newer psoriasis treatments can achieve greater levels of effcacy than older systemic therapies; however, current pso-riasis costs are substantial. We sought to estimate costs per additional responder associated with ixekizumab and etan.......

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Original Article

A Systematic Review of Lower Lip Anatomy, Mechanics of Local Flaps, and Special Considerations for Lower Lip Reconstruction

Boukovalas, S. et al.

Reconstruction of defects of the lower lip can be very challenging. The aim of this review is to analyze the unique characteristics of lower lip anatomy and provide a systematic approach for lower lip reconstruction. A review of current literature.......

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Original Article

"Deep Heating” Noninvasive Skin Tightening Devices: Review of Efectiveness and Patient Satisfaction

Chilukuri, S. et al.

Non-surgical aesthetic devices intended for treatment of lax and loose skin have gained popularity due to their ability to non-invasively improve patient’s aesthetic condition and its low side effect profle. This study is intended to review availa.......

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Original Article

Long-Term Follow-up of Onychomycosis Patients Treated With Efinaconazole

Pollack, R.A. et al.

Background: Onychomycosis is a common disease that remains difficult to treat despite the introduction of new topical agents. Clinical trials on efinaconazole and tavaborole included 48 weeks’ daily treatment regimens with a 4-week follow-up. It has .......

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Original Article

Patient Awareness of Local Drug Price Variation and the Factors That Influence Pharmacy Choice: A Cross-sectional Survey Study

Brodsky, S.D. et al.

Background: High out-of-pocket drug expenditures are increasingly common in dermatology. Patients may not be aware that prices vary among pharmacies and consequently may not shop for the lowest cost.

Objective: To determine what factors .......

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