Current Issue
February 2020 | Volume 19 | Issue 2
Editorials
Is Dupilumab an Immunosuppressant?
Atopic dermatitis (AD) is a chronic, immune-related, inflammatory skin disease that significantly reduces quality of life. In severe AD, systemic immunosuppressants are often utilized, though they do ...
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Universal Protocol in Mohs Micrographic Surgery: Incorporating a “Time Out” Procedure in Histopathologic Interpretation
In this publication, the IOM recognized that mistakes or failures to prevent mistakes were mostly caused by flawed systems, processes, and conditions. It outlined a four-tiered approach to improve saf...
Read MoreA Survey of Dermatologists’ Preparedness for Natural and Manmade Disasters
Natural and manmade disasters cause a range of dermatologic manifestations, including secondary infections after a flood,1 irritation from blistering agents used in chemical warfare,2<...
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Original Articles
Randomized, Investigator-Blinded Study to Compare the Efficacy and Tolerance of a 650-microsecond, 1064-nm YAG Laser to a 308-nm Excimer Laser for the Treatment of Mild to Moderate Psoriasis Vulgaris
BACKGROUND: Phototherapy is a safe and effective modality for the treatment of mild to moderate psoriasis.
OBJECTIVES: To compare the efficacy and safety of the 650-microsecond, 1064-nm pu...
Read MoreClinical and Molecular Effects of Interleukin-17 Pathway Blockade in Psoriasis
The interleukin-17 (IL-17) pathway plays a crucial role in the development of psoriasis. Briefly, naive T cells differentiate into helper T (Th17) cells through interaction with activated dendritic ce...
Read MoreManagement of Residual Psoriasis in Patients on Biologic Treatment
While biologics are highly effective, most psoriasis patients do not achieve complete skin clearance with their biologic monotherapy. How to achieve complete skin clearance in psoriasis patients who f...
Read MoreReal-World Clinical Experience With the IL-17 Receptor A Antagonist Brodalumab
Psoriasis is a chronic, inflammatory, remitting/relapsing autoimmune dermatologic condition that manifests with scaly, erythematous plaques. It has a significantly negative effect on patient quality o...
Read MoreLong-Term Efficacy and Safety of Superficial Radiation Therapy in Subjects With Nonmelanoma Skin Cancer: A Retrospective Registry Study
BACKGROUND: Low-dose superficial radiation therapy (SRT) effectively treats nonmelanoma skin cancer (NMSC) without requiring invasive...
Read MoreEffect of Calcipotriene/Betamethasone Dipropionate 0.005%/0.064% Foam on Target Lesions in Plaque Psoriasis: A Post-Hoc Analysis
OBJECTIVE: Investigate the effect of fixed-combination calcipotriene 0.005% plus betamethasone dipropionate 0.064% (Cal/BD) foam on target lesion severity in plaque psoriasis.
DESIGN: Post-hoc a...
Read MoreIngenol Mebutate: Expanded Utility
Ingenol mebutate (IM) is a novel drug that was developed for the treatment of actinic keratosis (AK). The drug works by a dual mechanism of action -- a rapid induction of cell death by necrosis along ...
Read MoreMelasma’s Impact on Quality of Life
Melasma is a commonly acquired condition that mostly affects women with Fitzpatrick skin types III-VI with prominent brown pigmentation with or without an underlying erythema. Despite multiple treatme...
Read MorePneumatic Delivery of Hyaluronan for Skin Remodeling: A Comparative Review
Jet Volumetric Remodeling (JVR) utilizes the principle of superficial soft tissue delivery of fluids, such as hyaluronic acid (HA) and other therapeutic materials. Dermal delivery of HA activates fibr...
Read MoreMultidisciplinary Real-World Experience With Bilastine, a Second Generation Antihistamine
Introduction: Allergic conditions frequently require treatment with antihistamines. First-generation antihistamines can potentially in-terfere with restful sleep, cause “mo...
Read MoreCase Reports
Successful Management of Anti-TNF-Induced Psoriasis Despite Continuation of Therapy in a Pyoderma Gangrenosum Patient
Pyoderma gangrenosum is an inflammatory, neutrophil-mediated disorder that is difficult to treat. Tumor necrosis factor and other inflammatory mediators are among the most promising therapeutic target...
Read MoreIntralesional Triamcinolone Acetonide in the Treatment of Traction Alopecia
Traction alopecia (TA) is a form of hair loss caused by continuous and prolonged tension to the hair, most commonly seen in Black/African American women and children who wear hairstyles that pull exce...
Read MoreRecurrent Squamous Cell Carcinoma Arising Within a Linear Porokeratosis
Here we report a case of linear porokeratosis with recurrent malignant degeneration to squamous cell carcinoma (SCC) recurring six years after excision of initial SCC. A 79-year-old woman presented wi...
Read MoreCombination Topical Chemotherapy for the Treatment of an Invasive Cutaneous Squamous Cell Carcinoma
INTRODUCTION: Standard of care for squamous cell carcinoma (SCC) is usually surgical, with either excision or Mohs micrographic surgery. However, surgery may not be ideal for elderly patients with num...
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Supplements
Compounding Conundrums: What the Future Holds
In-office compounding, once part and parcel of dermatologic practice, has become increasingly controversial—and confusing. As a result of legitimate public health concerns, FDA scrutiny began wi...
Read MoreTo Compound or Not to Compound
In-office compounding, once part and parcel of dermatologic practice, has become increasingly controversial—and confusing. As a result of legitimate public health concerns, FDA scrutiny began wi...
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