Category

Featured Articles

Recommendations for Preparing a Disaster Response Plan

By Aesthetics, COVID 19, Featured Articles, The Latest No Comments

Featured Article

Featured Article

In a paper recently published by JDD, several experts developed a guide based on their own experiences navigating the challenges of this past year.

In a paper recently published by JDD, several experts developed a guide based on their own experiences navigating the challenges of this past year.

Heather Onorati

The  suddenness with which offices closed as the COVID-19 pandemic escalated created many questions for practices. The uncertainty and inconsistencies around staffing procedures and reopening protocols added to the anxiety and emphasized the need to have proactive strategies in place for emergency situations.

In a paper recently published by JDD, Aesthetic Office Disaster Preparedness and Response Plan, several experts developed a guide based on their own experiences navigating the challenges of this past year.

“This advisory guide is meant to provide aesthetic physicians and their staff with a practical approach for practice management, staffing, supplies and inventory, and patient management,” the authors write in their paper titled “Aesthetic Office Disaster Preparedness and Response Plan.” They add that the paper does not set a standard of practice, but rather offers recommendations for various office procedures to have in place before a disaster-related event.

The experts classified their recommendations into four general areas: Practice Management; Supplies and Inventory; Office Staffing Considerations and Protocols; and Patient Management Strategies.

Among their many recommendations, they suggest creating several lists to serve as references in the event of an emergency. These include:

  • Site access lists — log-in information and passwords to social media sites and other web-based office accounts
  • Contact lists — staff contact details; office insurance policy contacts; financial institutions; colleagues who can be reached for assistance or guidance; state and national agencies like the Centers for Disease Control and Prevention, Federal emergency Management Agency, Department of Public Health), Department of Labor, etc.
  • Supply lists — office-related items in staff possession, inventory of general medical supplies including quantities and expiration dates

Additionally, the authors suggest pre-planning protocols for emergency staffing and office-hours as well as methods for communicating these to both staff and patients at the onset of a disaster.

“In situations of office closure or limited patient accessibility, the staff should be prepared to quickly switch to virtual access patient management tools such as telemedicine appointments,” the authors write.

Among their many additional suggestions, the authors offer insight into financial considerations, office medical record policies and procedures, how much to stock of various emergency supplies and more.

“We are hopeful that this provides at least a template of items for consideration and implementation across the various practice situations and emergencies and mitigates the reoccurrence of difficult lessons learned from the COVID-19 pandemic,” they write.

Heather Onorati is an experienced medical writer and editor with more than 20 years covering the dermatology industry.
Articles Cited in this Post

 

Aesthetic Office Disaster Preparedness and Response Plan

The coronavirus pandemic (COVID-19) has served as a call-to-arms in preparing practices for the next disaster whether it is another infectious disease or a flood, hurricane, earthquake, a sustained power outage, or something else. A group of predominantly core aesthetic physicians discussed the various aspects of their office procedures that warrant consideration in a proactive approach to the next pandemic/disaster-related event. This guide does not set a standard of practice but contains recommendations that may avoid some of the “lessons learned” with the COVID-19 pandemic.
Read More

You May Also Like

Recommendations for Preparing a Disaster Response Plan

| Aesthetics, COVID 19, Featured Articles, The Latest | No Comments
In a paper recently published by JDD, several experts developed a guide based on their own experiences navigating the challenges of this past year. In a paper recently published by…
Dermatologist looking at skin

What’s New in Dermatology – January 2021

| Featured Articles, The Latest | No Comments
In the January 2021 issue of the JDD, groups of experts reflect on lessons learned this year in several articles offering guidance and recommendations for practice management and patient care…

Top 10 Most Talked About Articles of 2020

| Featured Articles, The Latest | No Comments
As 2020 comes to a close, we are excited as we look to 2021. We are incredibly grateful to the researchers who have chosen to publish their work with JDD.…
Dermatologist looking at skin

What’s New in Dermatology – January 2021

By Featured Articles, The Latest No Comments

Featured Article

Featured Article

Dermatologist looking at skin

In the January 2021 issue of the JDD, groups of experts reflect on lessons learned this year in several articles offering guidance and recommendations for practice management and patient care moving into the future. While in other articles, investigators share findings that aim to improve disease understanding and patient care.

In the January 2021 issue of the JDD, groups of experts reflect on lessons learned this year in several articles offering guidance and recommendations for practice management and patient care moving into the future. While in other articles, investigators share findings that aim to improve disease understanding and patient care.

 

Heather Onorati

January always represents new beginnings. It’s the time of year we tend to reflect on the past, extract insight from experience and look toward the future with new hope and understanding. It is with this in mind that our January issue couples articles based in foresight and advances.

Groups of experts reflect on lessons learned this year in several articles offering guidance and recommendations for practice management and patient care moving into the future. While in other articles, investigators share findings that aim to improve disease understanding and patient care.

In Aesthetic Office Disaster Preparedness and Response Plan, authors look to their shared experiences to provide suggestions for a proactive approach to manage possible future disaster-related events that could affect aesthetic practice operations and financial viability. Leveraging Virtual Boot Camp to Alleviate First Year Dermatology Resident Anxiety illustrates compelling levels of anxiety among incoming first-year dermatology residents and suggests that formally addressing the tenets of the specialty at the onset of PGY-2 can strengthen the foundation and boost the confidence of trainees. And, in Prescribing Isotretinoin for Transgender Patients: A Call to Action and Recommendations, authors discuss how the field of dermatology must remain on the leading edge of patient safety and advocacy issues and remain compassionate and adaptable when facing new patient care issues.

In the spirit of advancing understanding, other articles look to build the knowledge well around therapeutic techniques and disease treatment. As we continue toward a better understanding COVID-19, New York and Brazilian researchers examine the cutaneous presentations that could be clues to diagnosis in Presentation and Management of Cutaneous Manifestations of COVID-19. In the article Aesthetic ONE21 Technique for Injecting IncobotulinumtoxinA into the Forehead: Initial Experience With 86 Patients, authors report safety and efficacy from a single-center, retrospective study. Researchers present a clinical evaluation of a drug-device combination product for the topical treatment of molluscum contagiosum in A Phase 2 Open-Label Study to Evaluate VP-102 for the Treatment of Molluscum Contagiosum.

In addition, experts examine the impact of psychosocial stress on skin health, investigate efficacy of a nutraceutical supplement for promoting hair growth, discuss recommendations for absorbable suspension sutures in nonsurgical facial rejuvenation, and much more.

Heather Onorati is an experienced medical writer and editor with more than 20 years covering the dermatology industry.
January 2021 JDD 

 

Editorials

Original Articles

Case Reports

Supplements

You May Also Like

Recommendations for Preparing a Disaster Response Plan

| Aesthetics, COVID 19, Featured Articles, The Latest | No Comments
In a paper recently published by JDD, several experts developed a guide based on their own experiences navigating the challenges of this past year. In a paper recently published by…
Dermatologist looking at skin

What’s New in Dermatology – January 2021

| Featured Articles, The Latest | No Comments
In the January 2021 issue of the JDD, groups of experts reflect on lessons learned this year in several articles offering guidance and recommendations for practice management and patient care…

Top 10 Most Talked About Articles of 2020

| Featured Articles, The Latest | No Comments
As 2020 comes to a close, we are excited as we look to 2021. We are incredibly grateful to the researchers who have chosen to publish their work with JDD.…

Top 10 Most Talked About Articles of 2020

By Featured Articles, The Latest No Comments

Featured Article

Featured Article

As 2020 comes to a close, we are excited as we look to 2021. We are incredibly grateful to the researchers who have chosen to publish their work with JDD. And, we look forward to continuing to play a role in highlighting the benefits of the most promising treatments for your patients in the New Year.  

As 2020 comes to a close, we are excited as we look to 2021. We are incredibly grateful to the researchers who have chosen to publish their work with JDD. And, we look forward to continuing to play a role in highlighting the benefits of the most promising treatments for your patients in the New Year.  

 

Heather Onorati

The second half of 2020 has seen the world still trying to navigate and overcome the COVID-19 pandemic, and the practice of dermatology has been no exception. However, while still an area of focus, dermatologists have been reading, sharing and discussing studies about a variety of other conditions and treatments relevant to their patients.  

In our year-end topten list, we’re sharing the case studies, reviews and investigations published by the Journal of Drugs in Dermatology that have been downloaded and read the most in the past 12 months.  

 

As the world sought to understand the emerging Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), or coronavirus disease 2019 (COVID-19), many potential signs and symptoms were investigated in connection with the virus, leading dermatologists to also grapple with identifying potentially afflicted patients. In a case study published early in the pandemic, authors in Cairo, Egypt, looked at whether a reported case of a pityriasis rosea-like rash could be connected with COVID-19. 

While COVID-19 remains a topic of interest, other issues like the use of neutraceuticals, approaches to treating melasma and hyperpigmentation, countering hair loss, and calming dermatitis have drawn attention.   

Nutrition and supplementation are topics of interest across medicine for their potential roles in overall health and wellness, including skincare. A literature review published in early 2019 examined the benefits of collagen supplementation in skin healing and anti-aging. The authors reported on a total of 11 studies that included 805 patients being treated for a range of issues from decubitus ulcers to anti-aging. In their analysis, the authors noted that collagen supplementation appeared to be promising with potential improvements in elasticity, hydration and dermal collagen density; however not all supplements are created equal and patients should be counselled with regard to ingredients and expectations, they noted. Another study that explored the use of a neutraceutical supplement for the treatment of hair loss highlighted botanical ingredients that may mitigate triggers for hair loss and help to restore balance to the follicle.   

In line with patient interest in “natural” treatments, investigators examined the mechanism of action for observed dermatologic benefits of colloidal oatmeal and found that extracts of colloidal oatmeal decreased pro-inflammatory cytokines in vitro. 

 

“Clinical evaluations showed that the colloidal oatmeal skin protectant lotion significantly improved dryness, scaling and roughness as early as 1 day after use, and these improvements were maintained over the duration of the study with continued use of the lotion,” the authors wrote. 

Among the investigations into treatments for common but challenging conditions, authors from the University of Kansas Medical Center, Kansas City, KS, reported on a case of chronic bilateral nasolabial fold seborrheic dermatitis. They hypothesized that Crisaborole 2% ointment, a PDE4 inhibitor would reduce the inflammation. After 2 treatments per week for 4 weeks, the investigators observed a notable reduction in scaling and erythema on the treatment site.  

Another commonly seen condition, xanthelasma palpebrae, can be a significant cosmetic concern for patients. In a case study published in 2016, researchers report on a case in which they used a hyfrecator for superficial tissue destruction resulting in excellent cosmetic results, the authors showed. 

Melasma and hyperpigmentation are among the challenging conditions dermatologists see. One study still garnering attention is an investigation into the benefit of Vitamin C plus iontophoresis. Investigators observed a mean 73% improvement in abnormal pigmentation after treatment combining Vitamin C with a full-face iontophoresis mask. A mean improvement of 15.7 on the Melasma Area and Severity Index was also noted.  

A review of 10 studies examining the efficacy of retinoids and azelaic acid for the treatment of acne and subsequent post-inflammatory hyperpigmentation in skin of color reported growing evidence that retinoids are well-tolerated and could be considered as first-line therapies to treat acne people with skin of color. In addition, azelaic acid may offer improvement in both acne and hyperpigmentation, the authors noted.  

Finally, a more recent review evaluated 35 randomized controlled trials of topical agents for the treatment of melasma found strong evidence for the recommendation of cysteamine, triple combination therapy, and tranexamic acid. 

As 2020 comes to a close, we are excited as we look to 2021. We are incredibly grateful to the researchers who have chosen to publish their work with JDD. And, we look forward to continuing to play a role in highlighting the benefits of the most promising treatments for your patients in the New Year. 

Heather Onorati is an experienced medical writer and editor with more than 20 years covering the dermatology industry.
Read the top 10 most discussed articles in 2020: 

 

You May Also Like

Recommendations for Preparing a Disaster Response Plan

| Aesthetics, COVID 19, Featured Articles, The Latest | No Comments
In a paper recently published by JDD, several experts developed a guide based on their own experiences navigating the challenges of this past year. In a paper recently published by…
Dermatologist looking at skin

What’s New in Dermatology – January 2021

| Featured Articles, The Latest | No Comments
In the January 2021 issue of the JDD, groups of experts reflect on lessons learned this year in several articles offering guidance and recommendations for practice management and patient care…

Top 10 Most Talked About Articles of 2020

| Featured Articles, The Latest | No Comments
As 2020 comes to a close, we are excited as we look to 2021. We are incredibly grateful to the researchers who have chosen to publish their work with JDD.…

Time Intervals Until the First Return Office Visit After New Medications

By Featured Articles No Comments

Featured Article

Featured Article

Making contact with patients within a week of prescribing a new medication may improve treatment adherence, suggest the authors of a recent study.

Read more

Making contact with patients within a week of prescribing a new medication may improve treatment adherence, suggest the authors of a recent study.

Heather Onorati

Making contact with patients within a week of prescribing a new medication may improve treatment adherence, suggest the authors of a recent study.

In patients with acne, atopic dermatitis and psoriasis, specifically, poor adherence to topical treatments has been a common challenge, according to studies. One reported reason is dissatisfaction with treatment efficacy. Closing the gap between prescription and follow-up visit may encourage patients to fill prescriptions sooner; initial efficacy may motivate further compliance, according to the study.

“Shortening the time to the first return visit may make doing the treatment appear to be less burdensome,” write Steven R. Feldman, M.D., Ph.D., and colleagues.

The group analyzed data representing 10.9 million estimated visits that were logged in the National Ambulatory Medical Care Survey and represented diagnoses for acne, atopic dermatitis and psoriasis between the years 2014 and 2016, which was the most recent available data. The time to a first return visit for patients with acne, atopic dermatitis and psoriasis who were prescribed at least one new medication was often more than two months regardless of whether they were prescribed a new medication.

Whether reasons for scheduling long intervals are due to tradition or unawareness of more optimal timeframes is not well known, the authors write.

Previous studies have indicated that adherence increases around the time of an office visit and then decreases rapidly in the days afterward, they note. Physicians may be able to use this tendency to create accountability for patients to begin and continue treatments.

“If a decreased interval between office visits can improve initial adherence, patients may see greater efficacy when using medications and be encouraged to continue their treatments,” the authors write.

While in-person follow-up visits may not be feasible for all patients due to travel distance, cost or other barriers, the authors note other methods of contacting and engaging the patient that have been shown to improve adherence, such as phone calls, emails, text messages and telemedicine visits.

“A lack of accountability may be an underappreciated component of non-adherence,” the authors write. “The timing of return visits may be an important factor to consider … for overcoming the adherence hurdle.”

Read Full Article Now
Heather Onorati is an experienced medical writer and editor with more than 20 years covering the dermatology industry.
Article Cited in this Post

You May Also Like

Recommendations for Preparing a Disaster Response Plan

| Aesthetics, COVID 19, Featured Articles, The Latest | No Comments
In a paper recently published by JDD, several experts developed a guide based on their own experiences navigating the challenges of this past year. In a paper recently published by…
Dermatologist looking at skin

What’s New in Dermatology – January 2021

| Featured Articles, The Latest | No Comments
In the January 2021 issue of the JDD, groups of experts reflect on lessons learned this year in several articles offering guidance and recommendations for practice management and patient care…

Top 10 Most Talked About Articles of 2020

| Featured Articles, The Latest | No Comments
As 2020 comes to a close, we are excited as we look to 2021. We are incredibly grateful to the researchers who have chosen to publish their work with JDD.…

Clinical Benefits of Circadian-based Antioxidant Protection and Repair

By Featured Articles, The Latest No Comments

Featured Article

Featured Article

Skin activities follow endogenous circadian rhythms resulting in differences between daytime and nighttime properties. To address the variations in skin needs, a novel circadian-based dual serum system (LVS) was developed.

Read more

Skin activities follow endogenous circadian rhythms resulting in differences between daytime and nighttime properties. To address the variations in skin needs, a novel circadian-based dual serum system (LVS) was developed.

Zoe Diana Draelos, Elizabeth T Makino, Kuniko Kadoya, Audrey Nguyen, Lily I Jiang, Rahul C Mehta 

 

The concept of human body rhythms has been popularized as important in overall body health. These rhythms are characterized as fluctuations in mental, physical, and emotional well-being based on the clock. These fluctuations are related to the day/night cycle, hormones, meals, sleep/wake cycle, adrenal gland production, thyroid gland, and clock genes.

The study of the body circadian rhythm is known as chronobiology with studies of the body’s inner clock dating back to the 18th century. There are three types of chronobiology rhythms: infradian rhythms, ultraradian rhythms, and circadian rhythms. Infradian rhythms last more than 24 hours and are repeated only every few days, weeks, or months representing such activities as female menses. Ultradian rhythms are shorter than 24 hours and often last several hours, such as ingestion of food. Finally, circadian rhythms last 24 hours with distinctive day/night cycles.

Circadian rhythms are endogenous and adjusted to the local environment by cues call zeitgebers, meaning “time giver” in German. The 2017 Nobel prize in physiology or medicine was awarded for research in molecular mechanisms controlling circadian rhythms in fruit flies. In humans, the circadian clock is in the suprachiasmatic nucleus, located in the hypothalamus. Information is transmitted to the suprachiasmatic nucleus via the retina that contains specialized photosensitive ganglion cells. PER1 and PER2 genes are expressed in the suprachiasmatic nucleus representing the primary circadian pacemaker in the human brain. These circadian rhythms are also important in the skin with robust autonomic clocks in keratinocytes, fibroblasts, melanocytes, mast cells, and hair follicles.

Important skin functions affected by circadian rhythms include free radical production and neutralization, DNA damage and repair, keratinocyte/fibroblast differentiation and proliferation, and barrier and immune functioning. Direct and indirect antioxidant protection play an important role in supporting these circadian rhythm skin functions.

Read Full Article Now
Article Cited in this Post

You May Also Like

Recommendations for Preparing a Disaster Response Plan

| Aesthetics, COVID 19, Featured Articles, The Latest | No Comments
In a paper recently published by JDD, several experts developed a guide based on their own experiences navigating the challenges of this past year. In a paper recently published by…
Dermatologist looking at skin

What’s New in Dermatology – January 2021

| Featured Articles, The Latest | No Comments
In the January 2021 issue of the JDD, groups of experts reflect on lessons learned this year in several articles offering guidance and recommendations for practice management and patient care…

Top 10 Most Talked About Articles of 2020

| Featured Articles, The Latest | No Comments
As 2020 comes to a close, we are excited as we look to 2021. We are incredibly grateful to the researchers who have chosen to publish their work with JDD.…

Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

By Atopic Dermatitis, Featured Articles, The Latest No Comments

Featured Article

Featured Article

Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various mechanisms of action including direct anti-inflammatory, anti-pruritic, anti-oxidant, anti-fungal, pre-biotic, barrier repair properties, and beneficial effects on skin pH. These have been shown to be of particular benefit in the treatment of atopic dermatitis.

Read more

Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various mechanisms of action including direct anti-inflammatory, anti-pruritic, anti-oxidant, anti-fungal, pre-biotic, barrier repair properties, and beneficial effects on skin pH. These have been shown to be of particular benefit in the treatment of atopic dermatitis.

Blair Allais MD, Adam Friedman MD FAAD

 

 

Oatmeal has a longstanding and rich history pertaining to its dermatologic use. The first documentation of oatmeal for skin health dates back as early as 2000 BC in Arabia and Egypt, where it was described as soothing and protecting in dry or itchy, inflamed skin. Oatmeal flour was subsequently recognized as a topical therapy for a variety of dermatologic conditions in Roman medical literature. The first scientific studies on the skin benefits of oatmeal appeared in the 1930s, including information about the cleansing properties of oatmeal, its role in relieving itch, and its function as a skin protectant.

In the 1940s and 1950s colloidal oatmeal became commercially available both in powder form and mixed with emollient oils, instigating medical studies examining the benefits of colloi-dal oatmeal baths in various xerotic dermatoses.

The results of this open-label clinical study suggest that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen including SPF 30 sun protection.

In 1989, the United States Food and Drug Administration (FDA) approved colloidal oatmeal as a safe and effective over-the-counter drug. In 2003, the FDA noted that colloidal oatmeal could relieve irritation and itching due to a number of dermatoses, providing temporary skin protection.5 Colloidal oatmeal is one of the few products that the FDA recognizes as a safe over the counter treatment. Today it is available in various forms including creams, lotions, shampoos, shaving gels, bath treat-ments, and body wash.

Colloidal oatmeal is the powder obtained from the grinding and processing of whole oat grain. Under strict protocols es-tablished by the US Pharmacopeia, oat grain is ground and processed until no more than 3% of the total particles in the powder exceed 150 μm in size and no more than 20% exceed 75 μm in size.6 The small size of the particles contributes to their ability to deposit on the skin and form an occlusive barrier when dispersed in water. Oat is composed of various types of phytochemicals, which contribute to its wide-ranging function and clinical use. Col-loidal oatmeal consists of sugars and amino acids (65%), proteins (15–20%), lipids (11%), and fiber (5%).7 The most important groups of phytochemicals present in oats include phenolics, β-glucans, lignans, avenanthramides, carotenoids, vitamin E, and phytosterols.

Of the phenolics present in oats, ferulic acid and caffeic acid are strong antioxidants, and fe-rulic acid also has UV absorbing properties.8 Flavonoids, a group of phenolic compounds present in oat, also are capable of absorbing ultraviolet A light from 320–370 nm. β-glucans are polysaccharides of D-glucose monomers and have a high viscosity largely due to their β-(1–3)-linkages.This viscosity contributes to the water-binding properties of oat. Oats also contain a wide range of minerals and vitamins, of which vita-min E is the most clinically relevant. Vitamin E is a naturally occurring antioxidant that protects against oxidative stress, inflammation, and photo-induced aging.

Learn more about the history, basic science, mechanism of Action, and clinical efficacy of colloidal oatmeal in the treatment of Atopic Dermatitis now.

Read Full Article Now
Article Cited in this Post

You May Also Like

Recommendations for Preparing a Disaster Response Plan

| Aesthetics, COVID 19, Featured Articles, The Latest | No Comments
In a paper recently published by JDD, several experts developed a guide based on their own experiences navigating the challenges of this past year. In a paper recently published by…
Dermatologist looking at skin

What’s New in Dermatology – January 2021

| Featured Articles, The Latest | No Comments
In the January 2021 issue of the JDD, groups of experts reflect on lessons learned this year in several articles offering guidance and recommendations for practice management and patient care…

Top 10 Most Talked About Articles of 2020

| Featured Articles, The Latest | No Comments
As 2020 comes to a close, we are excited as we look to 2021. We are incredibly grateful to the researchers who have chosen to publish their work with JDD.…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

By Featured Articles No Comments

Featured Article

Featured Article

Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been rising.

Read more

Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been rising.

Franchesca D. Choi BS RPh, Calvin T. Sung BS, Margit L.W. Juhasz MD, Natasha Atanaskova Mesinkovska MD PhD

 

 In 2016, the collagen market was valued at an estimated 3.71 billion USD and is projected to reach 6.63 billion USD by 2025. Collagen supplements, originating from various sources (eg, porcine, bovine, marine) and available in numerous formulations (eg, protein, gelatin, hydrolysate, peptides), are marketed as improving skin integrity and modulating skin aging. However, even with this increase in patient interest and market share, the use of collagen supplementation in dermatology remains controversial due to the lack of regulation on quality and quantity of ingredients in over-the-counter collagen supplements, as well as minimal peer-reviewed literature on the subject.

Fortunately, there are increasing numbers of clinical studies regarding potential effects of collagen-based dietary supplements on skin. Collagen is the most abundant component of the extracellular matrix constituting 75% of skin’s dry weight.5 Qualitative and quantitative decline in collagen is associated with cutaneous aging.6 Collagen protein is a right-handed triple helix of parallel polypeptides where every third amino acid residue is glycine (Gly) resulting in X-Y-Gly triplets, where X andY are frequently proline (Pro) and 4-hydroxyproline (Hyp; an amino acid sub- unit unique to collagen), respectively,7 making Pro-Hyp-Gly the most common amino acid triplet unit found in collagen

Native, animal collagen can be extracted from connective tissue in various forms.10 When denatured by heat, collagen forms gelatin, which has been used for centuries as a food source and traditional medicine in Europe and China.

Further enzymatic hydrolysis of gelatin produces collagen hydrolysates (CH) composed of peptides of varying lengths. CH has a lower molecular weight than gelatin, higher water-solubility, and no gelation properties at ambient temperatures, allowing CH to be conveniently formulated into liquid drinks and jelly sticks for oral consumption. In the past decade, CHs have gained popularity as a nutraceutical supplement.

Read Full Article Now
Article Cited in this Post

You May Also Like

Recommendations for Preparing a Disaster Response Plan

| Aesthetics, COVID 19, Featured Articles, The Latest | No Comments
In a paper recently published by JDD, several experts developed a guide based on their own experiences navigating the challenges of this past year. In a paper recently published by…
Dermatologist looking at skin

What’s New in Dermatology – January 2021

| Featured Articles, The Latest | No Comments
In the January 2021 issue of the JDD, groups of experts reflect on lessons learned this year in several articles offering guidance and recommendations for practice management and patient care…

Top 10 Most Talked About Articles of 2020

| Featured Articles, The Latest | No Comments
As 2020 comes to a close, we are excited as we look to 2021. We are incredibly grateful to the researchers who have chosen to publish their work with JDD.…

Revisiting Handwashing – As It Is Absolutely Essential

By Featured Articles, Global Health, The Latest No Comments

Featured Article

Featured Article

As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without a readily available, effective COVID-19 vaccine, and as the numbers of infected individuals continues to climb, the best practices to ensure public safety are rooted in good personal hygiene and prevention of transmission of the novel coronavirus SARS-CoV-2. To that end, in addition to properly wearing adequate facial covering, individuals should properly wash their hands to prevent direct auto-inoculation.

Read more

As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without a readily available, effective COVID-19 vaccine, and as the numbers of infected individuals continues to climb, the best practices to ensure public safety are rooted in good personal hygiene and prevention of transmission of the novel coronavirus SARS-CoV-2.

Graham L. Litchman DO MS, Justin W. Marson MD, Neal Bhatia MD, Brian Berman MD PhD

 

Despite being a technique widely taught from primary school-age, many individuals do not practice adequate hand hygiene and, even pre-pandemic, suffered from economic losses of missed days at work and/or school.1 Study data have shown that the simple act of handwashing, regardless of other medical interventions, can reduce the transmission of respiratory viruses.2 Furthermore, handwashing with an adequate antimicrobial product for at least 20 seconds can reduce the risk of transmission of viruses, including respiratory viruses like SARS-CoV-2.

Consistent use of water and soap or alcohol-based sanitizer has been estimated by the World Health Organization (WHO) to reduce pathogen spread up to 50% among healthcare workers. Newer studies are now focusing on “virucidal” properties of alternative and novel agents and combinations.

The results of this open-label clinical study suggest that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen including SPF 30 sun protection.

Sodium hypochlorite (chemically known as NaOCl and more commonly referred to as “Liquid Bleach”), is a chlorine-derived product, that has been used as a disinfectant for over 200 years, and came to prominence in the 1930s. Open wounds were treated with hypochlorite solutions during World War I, which lead to more routine use within hospitals.6 This paired with aggressive marketing, ultimately lead to “Clorox” becoming the household name for a disinfectant.

The antimicrobial effects of these chlorine-derived products comes from their ability to disrupt the membranes of bacteria, fungi, and viruses as well as induce oxidative damage to the necessary proteins and enzymes for microbial survival.7 The strengths of chlorine-derived agents are determined by their concentration and the solvent (typically water) in which they are mixed. When NaOCl is added to water the reaction yields hypochlorous acid ion (HOCl) and sodium hydroxide (NaOH).

Because NaOCl is more stable, it usually predominates at equilibrium. However, in more acidic solvents, the concentration of HOCl increases. This increases the potency of the solution’s antimicrobial properties given that HOCl is 80–120 times more efficient at eliminating bacteria, viruses, and fungi than sodium hypochlorite. Hypochlorous acid on its own is far too caustic and is not appropriate for application to the skin or human body; consequently, it is reserved for disinfecting inanimate objects, demonstrating that its strength comes at a price.

Read Full Article Now
Article Cited in this Post

You May Also Like

Recommendations for Preparing a Disaster Response Plan

| Aesthetics, COVID 19, Featured Articles, The Latest | No Comments
In a paper recently published by JDD, several experts developed a guide based on their own experiences navigating the challenges of this past year. In a paper recently published by…
Dermatologist looking at skin

What’s New in Dermatology – January 2021

| Featured Articles, The Latest | No Comments
In the January 2021 issue of the JDD, groups of experts reflect on lessons learned this year in several articles offering guidance and recommendations for practice management and patient care…

Top 10 Most Talked About Articles of 2020

| Featured Articles, The Latest | No Comments
As 2020 comes to a close, we are excited as we look to 2021. We are incredibly grateful to the researchers who have chosen to publish their work with JDD.…

View the Latest Discoveries in Atopic Dermatitis, Anti-Aging, and Medical Dermatology

By Featured Articles, JDD Highlights No Comments

Dermatology News

JDD Highlights

The October issue of the Journal of Drugs in Dermatology is available now. This month, we focus on atopic dermatitis with special features on Public Health, Anti-aging, Aesthetic, and Medical Dermatology.

Read the October JDD Now

Atopic Dermatitis, Public Health, Anti-Aging, and Medical Dermatology

The October issue of the Journal of Drugs in Dermatology is available now. This month, we focus on atopic dermatitis, with special features on Public Health, Anti-aging, Aesthetic, and Medical Dermatology.

Article Highlights

 

Editor's Picks

You May Also Like

Insights On the Pediatric, Adolescent & Adult AD Patient

| Atopic Dermatitis, Podcast Highlights | No Comments
iTunes Google Play Stitcher TuneIn Dr. Peter Lio, Dr. Lindsay Finklea & Dr. Adam Friedman   You can't truly understand someone until you walk a mile in their shoes. This…

Recommendations for Preparing a Disaster Response Plan

| Aesthetics, COVID 19, Featured Articles, The Latest | No Comments
In a paper recently published by JDD, several experts developed a guide based on their own experiences navigating the challenges of this past year. In a paper recently published by…
Dermatologist looking at skin

What’s New in Dermatology – January 2021

| Featured Articles, The Latest | No Comments
In the January 2021 issue of the JDD, groups of experts reflect on lessons learned this year in several articles offering guidance and recommendations for practice management and patient care…

What are the Skincare Benefits of Niacinamide?

By Aesthetics, Featured Articles No Comments

Featured Article

Featured Article

A 2016 study from Journal of Drugs in Dermatology suggests that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen including SPF 30 sun protection.

Read more

A 2016 study from Journal of Drugs in Dermatology (“Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol“), which was recently cited in an article on Prevention.com, suggests that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen including SPF 30 sun protection. 

Patricia Farris MD, Joshua Zeichner MD, and Diane Berson MD

 

Consumers are increasingly interested in over-the-counter skin care products that can improve the appearance of photodamaged and aging skin. This 10-week, open-label, single- center study enrolled 25 subjects with mild to moderate hyperpigmentation and other clinical stigmata of cutaneous aging including fine lines, sallowness, lack of clarity, and wrinkling. Their mean age was 53.4±7.7 years. The test product contained retinol 0.5% in combination with niacinamide 4.4%, resveratrol 1%, and hexylresorcinol 1.1% in a moisturizing base. Subjects were provided a skin care regimen including a cleanser, hydrating serum, moisturizer, and an SPF 30 sunscreen for daily use. The test product was applied only at night.

The use of this skin brightening/anti-aging cosmeceutical was found to provide statistically significant improvements in all efficacy endpoints by study end. Fine lines, radiance, and smoothness were significantly improved as early as week 2 (P<.001). By week 4, hyperpigmentation, overall skin clarity, evenness of skin tone, and wrinkles showed statistically significant improvement compared to baseline. Mild retinoid dermatitis including flaking and redness occurred early in the study as reflected by tolerability scores. By week 10, subjects reported no stinging, itching, dryness, or tingling.

The results of this open-label clinical study suggest that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen including SPF 30 sun protection.

Read Full Article Now
Article Cited in this Post

You May Also Like

Recommendations for Preparing a Disaster Response Plan

| Aesthetics, COVID 19, Featured Articles, The Latest | No Comments
In a paper recently published by JDD, several experts developed a guide based on their own experiences navigating the challenges of this past year. In a paper recently published by…
Dermatologist looking at skin

What’s New in Dermatology – January 2021

| Featured Articles, The Latest | No Comments
In the January 2021 issue of the JDD, groups of experts reflect on lessons learned this year in several articles offering guidance and recommendations for practice management and patient care…

Top 10 Most Talked About Articles of 2020

| Featured Articles, The Latest | No Comments
As 2020 comes to a close, we are excited as we look to 2021. We are incredibly grateful to the researchers who have chosen to publish their work with JDD.…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

By Aesthetics, Featured Articles, New Articles No Comments

Featured Article

Featured Article

800 patients who took up to 10 grams of collagen per day, experienced improvement in skin elasticity, moisture retention, and increased density of collagen fibers in the skin.

Read more

Improvements in skin health is a well-researched benefit of taking collagen – in fact, according to a January 2019 Journal of Drugs in Dermatology study, (recently featured in an Every Day Health article, ” 8 Potential Benefits of Collagen – and 1 Thing it Can’t Do”), 800 patients who took up to 10 grams of collagen per day, experienced improvement in skin elasticity, moisture retention, and increased density of collagen fibers in the skin.

Franchesca D. Choi BS RPh, Calvin T. Sung BS, Margit L.W. Juhasz MD, Natasha Atanaskova Mesinkovska MD PhD

Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been rising.

In 2016, the collagen market was valued at an estimated 3.71 billion USD and is projected to reach 6.63 billion USD by 2025. Collagen supplements, originating from various sources (eg, porcine, bovine, marine) and available in numerous formulations (eg, protein, gelatin, hydrolysate, peptides), are marketed as improving skin integrity and modulating skin aging.

However, even with this increase in patient interest and market share, the use of collagen supplementation in dermatology remains controversial due to the lack of regulation on quality and quantity of ingredients in over-the-counter collagen supplements, as well as minimal peer-reviewed literature on the subject. Fortunately, there are increasing numbers of clinical studies regarding potential effects of collagen-based dietary supplements on skin.

Read Full Article Now
Article Cited in this Post

You May Also Like

Recommendations for Preparing a Disaster Response Plan

| Aesthetics, COVID 19, Featured Articles, The Latest | No Comments
In a paper recently published by JDD, several experts developed a guide based on their own experiences navigating the challenges of this past year. In a paper recently published by…
Dermatologist looking at skin

What’s New in Dermatology – January 2021

| Featured Articles, The Latest | No Comments
In the January 2021 issue of the JDD, groups of experts reflect on lessons learned this year in several articles offering guidance and recommendations for practice management and patient care…

Top 10 Most Talked About Articles of 2020

| Featured Articles, The Latest | No Comments
As 2020 comes to a close, we are excited as we look to 2021. We are incredibly grateful to the researchers who have chosen to publish their work with JDD.…

Impact of Iron-Oxide Containing Formulations Against Visible Light-Induced Skin Pigmentation in Skin of Color Individuals

By Aesthetics, Featured Articles, Photoprotection, Skin of Color No Comments

Featured Article

Featured Article

In this study, the efficacy of two formulations containing iron oxide was evaluated in preventing visible light-induced pigmentation compared with a non-tinted mineral SPF 50+ sunscreen.

Read more

In this study, the efficacy of two formulations containing iron oxide was evaluated in preventing visible light-induced pigmentation compared with a non-tinted mineral SPF 50+ sunscreen.

Hawasatu Dumbuya PhD, Pearl E Grimes MD, Stephen Lynch PhD, Kalli Ji PhD, Manisha Brahmachary PhD, Qian Zheng Md PhD, Charbel Bouez PhD, Janet Wangari-Talbot PhD

 

 

Visible light (400–700nm), which contributes to 45% of solar radiation, contributes to skin darkening and worsening of dyschromias, particularly in individuals with Fitzpatrick skin phototypes III and higher.

The pathogenesis of melasma is incompletely understood, which poses a challenge for disease management. Causative factors include genetics, ultraviolet (UV) radiation, cosmetics, pregnancy, hormonal therapy, phototoxic drugs, and various medications.

Currently, sunscreens provide limited protection against that spectrum. Due to their capabilities in absorbing, scattering, and reflecting visible light, topical products containing pigments and/or metal oxides can provide additional photoprotection.

In this study, the efficacy of two formulations containing iron oxide was evaluated in preventing visible light-induced pigmentation compared with a non-tinted mineral SPF 50+ sunscreen. Expert grading and colorimetry demonstrated that the iron-oxide containing formulations significantly protected against visible light-induced pigmentation compared to untreated skin or mineral SPF 50+ sunscreen in Fitzpatrick IV individuals.

Read Full Article Now
Article Cited in this Post

Open Access Articles

The Journal of Drugs in Dermatology (JDD) presents Open Access content, unrestricted access to our original articles, award-winning case studies, clinical trial reviews and clearance updates, drugs and devices, and special content geared toward medical residents and other allied health professionals.
Articles are reviewed by the Editorial Board of renowned experts, from key opinion leaders to well-known clinicians. View our open-access dermatology articles now.
View All Open Access Articles

You May Also Like

Recommendations for Preparing a Disaster Response Plan

| Aesthetics, COVID 19, Featured Articles, The Latest | No Comments
In a paper recently published by JDD, several experts developed a guide based on their own experiences navigating the challenges of this past year. In a paper recently published by…
Dermatologist looking at skin

What’s New in Dermatology – January 2021

| Featured Articles, The Latest | No Comments
In the January 2021 issue of the JDD, groups of experts reflect on lessons learned this year in several articles offering guidance and recommendations for practice management and patient care…

Top 10 Most Talked About Articles of 2020

| Featured Articles, The Latest | No Comments
As 2020 comes to a close, we are excited as we look to 2021. We are incredibly grateful to the researchers who have chosen to publish their work with JDD.…