INDIVIDUAL ARTICLE: Pediatric Atopic Dermatitis Patient Cases Integrating Ceramides-Containing Cleansers and Moisturizers into Prescription Treatment and Maintenance Approaches

December 2023 | Volume 22 | Issue 12 | SF389716s3 | Copyright © December 2023


Published online November 28, 2023

Lawrence A Schachner MD FAAD FAAPa, Anneke Andriessen PhDb, Madelyn Dones MD FAAPc, Mercedes E Gonzalez MD FAADd, Linda Keller MD FAAPe, Karan Lal MD MS FAADf, Peter Lio MD FAADg, Ayleen Pinera-Llano MD FAAPh, Latanya Benjamin MD FAAD FAAPi

aDivision of Pediatric Dermatology, Department of Dermatology and Cutaneous Surgery, Department of Pediatrics, Leonard M. Miller School of Medicine, University of Miami, FL
bRadboud UMC, Nijmegen and Andriessen Consultants, Malden, The Netherlands
cBaptist Health Hospital, Nicklaus Childrens’Hosptital, Miami, FL
dMedical Director, Pediatric Skin Research, Assistant Professor Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery at the University of Miami Miller School of Medicine Miami, FL
eBaptist Health Baptist Hospital, Baptist Health South Miami Hospital, Miami, FL
fSchweiger Dermatology Group, New York, NY
gClinical Assistant Professor of Dermatology & Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL
hKing Bay Pediatrics, Maimi, FL, General Pediatrics, Nicklaus Children's Hospital, Miami, FL
iAssociate Professor of Pediatric Dermatology, Department of Women's and Children's Health, Florida Atlantic University, Boca Raton, FL

REFERENCES

  1. Lloyd-Lavery A, Solman L, Grindlay DJC, et al. What’s new in atopic eczema? An analysis of systematic reviews published in 2016. Part 2: epidemiology, aetiology and risk factors. Clin Exp Dermatol. 2016;2019(44):363-369.
  2. Davies E, Rogers NK, Lloyd-Lavery A, et al. What’s new in atopic eczema? An analysis of systematic reviews published in 2015. Part 1: epidemiology and methodology. Clin Exp Dermatol. 2018;43(4):375-379. DOI: 10.1111/ced.13377
  3. Thorsteinsdottir S, Stokholm J, Thyssen JP, et al. Genetic, clinical, and environmental factors associated with persistent atopic dermatitis in childhood. JAMA Dermatol. 2018;155(1):50-57. DOI: 10.1001/jamadermatol.2018.4061
  4. Wollenberg A, Barbarot S, Bieber T, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol. 2018;32(5):657-682. DOI:10.1111/jdv.14891
  5. Wollenberg A, Barbarot S, Bieber T, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II. J Eur Acad Dermatol Venereol. 2018;32(6):850-878.
  6. Eichenfield LF, Tom WL, Berger TG, et al. Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol. 2014;71(1):116-132. DOI:10.1016/j.jaad.2014.03.023 
  7. Ma L, Li P, Tang J, et al. Prolonging time to flare in pediatric atopic dermatitis: A randomized, investigator-blinded, controlled, multicenter clinical study of a ceramide-containing moisturizer. Adv Ther. 2017;34(12):2601-2611. DOI:10.1007/ s12325-017-0640-6
  8. McClanahan D, Wong A, Kezic S, et al. A randomized controlled trial of an emollient with ceramide and filaggrinassociated amino acids for the primary prevention of atopic dermatitis in high-risk infants. J Eur Acad Dermatol Venereol. 2019;33(11):2087-2094. DOI:10.1111/jdv.15786
  9. Fitzpatrick TB. The validity and practicality of sun-reactive skin types I through VI. Arch Dermatol. 1988:124(6):869-871. 
  10. Baldwin HE, Bhatia ND, Friedman A, Eng RM, Seite S. The Role of cutaneous microbiota harmony in maintaining a functional skin barrier. J Drugs Dermatol. 2017;16(1):12-18. DOI:10.25251/skin.1.supp.138
  11. Di Domenico EG, Cavallo I, Bordignon V, et al. Inflammatory cytokines and biofilm production sustain Staphylococcus aureus outgrowth and persistence: a pivotal interplay in the pathogenesis of atopic dermatitis. Sci Rep. 2018;8(1):9573. DOI: 10.1038/s41598-018-27421-1
  12. Alexis AF, Woolery-Lloyd H, Andriessen A, et al. Insights in skin of color patients with atopic dermatitis and the role of skincare in improving outcomes. J Drugs Dermatol. 2022;21(5):462-470. DOI:10.36849/JDD.6609.
  13. Alexis AF, Woolery-Lloyd H, Williams K, et al. Racial/ ethnic variations in skin barrier: Implications for skin care recommendations in skin of color. J Drugs Dermatol. 2021;20(9):1-7. DOI:10.36849/JDD.6312]
  14. Lansang P, Lara-Corrales I, Bergman JN, et al. Approach to the assessment and management of pediatric patients with atopic dermatitis: a consensus document. Section IV: Consensus statements on the assessment and management of pediatric atopic dermatitis. J Cutan Med Surg. 2019;23(5_ suppl):32S-39S. DOI:10.1177/1203475419882654
  15. Zhong Y, Samuel M, van Bever H, Tham EH. Emollients in infancy to prevent atopic dermatitis: A systematic review and meta-analysis. Allergy. 2022;77(6):1685-1699. DOI:10.1111/ all.15116
  16. Schachner LA, Blume-Peytavi U, Andriessen A, et al. Expert consensus on ceramides containing skincare in newborns and infants and potential mitigation of atopic dermatitis. Ital J Dermatol Venerol. 2022;157:23-32.
  17. Lynde CW, Andriessen A. A cohort study on a ceramidecontaining cleanser and moisturizer used for atopic dermatitis. Cutis. 2014;93(4)207-2013.
  18. Kircik LH, Del Rosso JQ. Nonsteroidal treatment of atopic dermatitis in pediatric patients with a ceramide-dominant topical emulsion formulated with an optimized ratio of physiological lipids. J Clin Aesthet Dermatol. 2011;4:25–31.

AUTHOR CORRESPONDENCE

Anneke Andriessen PhD anneke.a@tiscali.nl
Close Menu