The case series discussed using CER-containing skincare as mono or adjunct to topical treatment in AD. A cohort study on a CER-containing cleanser and moisturizer as monotherapy demonstrated successful outcomes in adults and children with mild-to-moderate AD.17 A subgroup analysis of a CER-containing moisturizer study on efficacy and safety for children with mild-to-moderate AD showed that 34 (58%) had cleared after three weeks of mono-treatment.18 Parents of young children are often "stuck on" using specific products and sensitive, culturally influenced bathing and skincare practices.16 Advisors have found it helpful to defer the discussion about switching products until a rapport has been established with the parent. The advisors observed that parents might be used to the small quantities indicated for topical steroids, thus under-moisturizing their infants. Together with the type of skincare, the advisors provided education on the amount of moisturizer and when to apply it. Advisors strongly agreed on the importance of handouts to educate patients and parents, which should be customizable. When escalating patients to systemic medications for AD, advisors emphasized the importance of maintaining the skincare regimen.
Limitations
The presented cases illustrate the real-world experience of the advisors with their patients rather than reflect a controlled clinical trial data environment, nor do they mirror statistical outcomes. The use of the CER-containing cleanser and moisturizer is at the discretion of the treating healthcare professional.
The studies on CER-containing skincare for adults with AD were not included in the discussion.
CONCLUSION
The presented pediatric AD case series aims to educate healthcare providers treating newborns, infants, and children to tailor AD prescription, nonprescription therapy, skincare, and maintenance treatment to improve patient outcomes.
The six presented cases used skincare products containing lipids such as CERs to promote a healthy skin barrier, delaying flares, and improving outcomes. Sharing best practices in pediatric AD therapy, maintenance treatment, and implementation of consistent skincare use with CER-containing cleansers and moisturizers are important tools for healthcare providers to optimize care for pediatric patients with AD.
DISCLOSURES
The authors received an educational grant and skincare products used for the patient cases from CeraVe US. Parents/caregivers consented to use their child's case report and photographs. The authors contributed to the cases and permitted to use the photographs.
