For the response rates defined as “none or mild†as determined by the investigator (Figure 4, top) and the subject (Figure 4, bottom), there was a dose-response relationship with higher response rates with increasing INCO dose. The 75U group was comparable to 100U at some of the timepoints. High response rates were reached in all four dose groups after treatment even though most subjects (85.0%-86.9% per dose group) had a baseline FWS score of “severe†(Table 1) and thus needed at least a 2-point improvement (from a score of 2 or 3 to 0 or 1) to reach this response criterion.
