Facial Aging Improvement Case Study Using a Novel Combination of Retinol, Niacinamide, and Terminalia Chebula

July 2022 | Volume 21 | Issue 7 | 784 | Copyright © July 2022


Published online June 30, 2022

Marc Z. Handler MDa,b,c, Alison Adams-Woodford BA LEd, Patty Ayres LE CMLTe, Giorgiana Giancola PhDf, Isabel Diaz BAg

aDepartment of Dermatology, Metropolitan Hospital, New York, NY
bDepartment of Dermatology, Rutgers New Jersey Medical School, Newark, NJ
cDermatology, Hackensack Meridian School of Medicine, Nutley, NJ
dR&D and Communications, Physicians Care Alliance (PCA) Skin, Scottsdale, AZ
ePhysicians Care Alliance (PCA) Skin, Scottsdale, AZ
fScientific Affairs, Colgate-Palmolive Company, Piscataway, NJ
gDermal Clinical Research, Colgate-Palmolive Company, Piscataway, NJ




Visia® Filter Data
The Canfield Visia® assigns percentages to each participant’s photos at each time of imaging. A lower percentage indicates a worse condition in relation to other people of their age globally. Improvement is indicated by a percentage that increases, closer to 100%. The statistical analysis indicated significant improvement in brown spots (P=.002; Figure 3), rhytids (P=.002; Figure 4), and skin texture (P=.003). Directional improvement in red areas was indicated (P=.055).

Self-Assessment Questionnaire
The self-assessment questionnaires were completed at each visit. Participants were asked: "On a scale of zero to four, how would you rate the overall appearance of your facial skin? Zero - no improvement, One - mild improvement, Two - moderate improvement, Three - moderately significant improvement, Four - significant improvement”, at week 12, 100% of participants rated themselves a four, "significant improvement" (Figure 5).