Limitations
This physician-initiated study has several limitations. For example, the study design did not include the evaluation of comparators. Instead, the CER-containing skincare products were evaluated in subjects with DM-related xerosis in a realworld setting. Therefore, the present findings may not extend to other CER-containing skincare products manufactured with different formulations. Moreover, subjects' medical management of DM was not monitored throughout the study.
CONCLUSION
This international, multicenter, open-label cohort study showed
that the CER-containing cleanser and moisturizer per physician
and subject assessments were associated with statistically
significant improvements in DM-associated xerosis, patient
satisfaction with treatment outcomes, and improved QoL
aspects. In addition, subjects reported high adherence to the
skincare regimen. At EOS, 91.5% (483/528) of subjects indicated
that they would continue to use the CER-containing cleanser
and moisturizer to improve their DM-related xerosis.
