for chronic wounds and infection.12,13,16 Additionally, diabetic skin ages faster due to inflammation triggered by intrinsic and extrinsic factors.17,18
Gentle cleansers and moisturizers are recommended daily to restore and preserve skin barrier integrity in xerosis.5-7,19,21-23,25 Skincare, specifically CER-containing skincare, was shown to improve the clinical signs and symptoms of AD, including pruritus, erythema, and fissuring.7,6,24
The pathogenesis of pruritus in DM is not fully understood, and various factors contribute to the development of this symptom.4,12,26,27 Research suggests 2 main factors are associated with pruritus in DM: skin xerosis and diabetic polyneuropathy.4,12,26,27 Skincare use has been shown to reduce DM-related pruritus significantly.4 The present cohort showed that the CER-containing cleanser and moisturizer were associated with improvements in DM-associated xerosis severity and the reduction of pruritus.
