Total Defense + Repair: A Novel Concept in Solar Protection and Skin Rejuvenation

July 2015 | Volume 14 | Issue 7 | Supplement Individual Articles | 3 | Copyright © July 2015


David H. McDaniel MD FAAD,a Iltefat H. Hamzavi MD,b Joshua A. Zeichner MD,cSabrina G. Fabi MD FAAD FAACS,d Vivian W. Bucay MD,e Julie C. Harper MD,f Jody A. Comstock MD,g Elizabeth T. Makino BS CCRA MBA,h Rahul C. Mehta PhD,h and Virginia L. Vega PhDh

aMcDaniel Institute of Anti-Aging Research, Virginia Beach, VA
bDepartment of Dermatology, Henry Ford Hospital, Detroit, MI
cDepartment of Dermatology, Mount Sinai Hospital, New York, NY
dDepartment of Dermatology, San Diego, CA
eBucay Center for Dermatology and Aesthetics, San Antonio, TX
fDepartment of Dermatology, University of Alabama, Birmingham, AL
gSkin Spectrum, Tuczon, AZ
hResearch & Development, SkinMedica Inc., an Allergan Company, Irvine, CA

CONCLUSION

The deleterious effects of solar radiation are not linked exclusively to UVR. In vitro and clinical studies have shown that visible and IR radiations, as well as heat accumulation, are able to activate different signal transduction pathways, resulting in enhanced oxidative stress and premature aging. Chromophores for solar lights are localized in different cellular compartments, (ie, IR-A is mitochondrial cytochrome c complex, UVA is lipid in the biological membranes, and UVB is DNA in the nuclei), which strongly suggests a synergistic effect among these different types of radiation (UV + IR + visible + heat = 1+1+1+1=100). Thus, a sensitive approach to providing an efficacious and comprehensive solar protection is to generate SPF active ingredients with potent and efficacious antioxidants. TDR has a blend of antioxidants and special ingredients that complements SPF ingredients, redefining total (broad) solar protection. These antioxidants are the product of breakthrough technology, scientific research, and innovation, providing the next generation of multifunctional skin care products. SOL-IR Advanced Antioxidant Complex acts in harmony to diminish the signs of aging, providing an active superscreen effect that counterbalances the deleterious effects of free radicals on skin cells whilst promoting endogenous repair.

DISCLOSURES

Virginia L. Vega, Rahul Mehta, and Elizabeth T. Makino are employees of SkinMedica, an Allergan Company. David Mc Daniel was a MAB for Juvederm Voluma and has performed other consulting work for Allergan and SkinMedica.

ACKNOWLEDGMENTS

We would like to thank Kuniko Kadoya PhD and Robin Gunawan for providing us with unpublished data, and Samantha Widdicombe for her administrative support.

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