Total Defense + Repair: A Novel Concept in Solar Protection and Skin Rejuvenation

July 2015 | Volume 14 | Issue 7 | Supplement Individual Articles | 3 | Copyright © July 2015


David H. McDaniel MD FAAD,a Iltefat H. Hamzavi MD,b Joshua A. Zeichner MD,cSabrina G. Fabi MD FAAD FAACS,d Vivian W. Bucay MD,e Julie C. Harper MD,f Jody A. Comstock MD,g Elizabeth T. Makino BS CCRA MBA,h Rahul C. Mehta PhD,h and Virginia L. Vega PhDh

aMcDaniel Institute of Anti-Aging Research, Virginia Beach, VA
bDepartment of Dermatology, Henry Ford Hospital, Detroit, MI
cDepartment of Dermatology, Mount Sinai Hospital, New York, NY
dDepartment of Dermatology, San Diego, CA
eBucay Center for Dermatology and Aesthetics, San Antonio, TX
fDepartment of Dermatology, University of Alabama, Birmingham, AL
gSkin Spectrum, Tuczon, AZ
hResearch & Development, SkinMedica Inc., an Allergan Company, Irvine, CA

Heat-Thermal Aging

Solar IR radiation transmits heat energy that is responsible for raising skin temperatures to levels close to or higher than 40°C.3,8,41 Chronic increases in skin temperatures are associated with “erythema ab igne,” a pathology that is characterized by reticular pigmentation of the skin and by the presence of dermal solar elastosis similar to that seen in photoaged skin. Thus, heat-linked premature aging of the skin has been reported on baker’s arms and on the faces of glass blowers, supporting the concept of thermal-aging or premature aging being triggered by heat. IR-associated increase in temperature is mainly associated with IR-B and IR-C, which are absorbed by the epidermis.41
table 1
Heat-related skin damage is characterized by an increased expression of MMPs, more specifically MMP1, MMP-3, and MMP-12, resulting in the destruction of collagen and elastin.43,44 In addition, heat also promotes dermal expression of tropoelastin while decreasing fibrillin-1 levels, resulting in the accumulation of elastotic material.44 Increased ROS production by heat is
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