Topical S. aureus – Targeting Endolysin Significantly Improves Symptoms and QoL in Individuals With Atopic Dermatitis

December 2021 | Volume 20 | Issue 12 | Original Article | 1323 | Copyright © December 2021


Published online November 29, 2021

Magali Moreau PhD,a Sophie Seité PhD,b Luc Aguilar PhD,c Olivier Da Cruz MSc,d Julia Puech PharmD,d Johan Frieling MD PhD,e Ann’Laure Demessant PharmDb

aL’Oréal Recherche & Innovation, Clark, NJ
bLa Roche Posay Dermatological Laboratories, Levallois Perret, France
cL'Oreal R&I, Aulnay-Sous-Bois, France
dL’Oréal R&I, Chevilly Larue, France
eMicreos Human Health, Bilthoven,The Netherlands

In total, 43 people [22 adults (mean age, 33.7) and 21 children (mean age, 5.7)] were included and completed the clinical study, all presenting comparable disease severity at baseline (see SCORAD -Table 1).The participants reported applying the study product two to three times daily on average during the study period.

Overall, the study product was well tolerated, and no adverse events related to it occurred. Nine participants reported some cutaneous discomfort, redness, small pimples, or dryness, which were judged to be expected and frequently encountered in patients with mild AD.

The study product rapidly reduced disease severity in a