The Importance of Photoprotection and Moisturization in Treating Acne Vulgaris

August 2014 | Volume 13 | Issue 8 | Supplement Individual Articles | 89 | Copyright © August 2014


Whitney P. Bowe MDa and Leon H. Kircik MDb

aIcahn School of Medicine at Mount Sinai, New York, NY
bIcahn School of Medicine at Mount Sinai, New York, NY; Indiana University School of Medicine, Indianapolis, IN;
Physicians Skin Care, PLLC, Louisville, KY

Licorice derivatives are increasingly used in therapeutic and cosmeceutical formulations for their anti-inflammatory effects and skin brightening effects.27 Acne vulgaris is characteristic of excess sebum production and the induction of inflammatory reactions via the cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2 ) pathway.28 To counteract this inflammatory cascade, licorice derivatives have demonstrated the capacity to suppress the inflammatory responses of the COX-2 and PGE2 pathway.26
The herbal formulations of G glabra have also been used to treat a number of dermatologic disorders, including dermatitis, eczema, pruritus, and cysts.29 Moreover, G glabra has demonstrated considerable antibacterial activity against Propionibacterium acnes that resulted in a minimal induction of resistance when compared with the marked development of resistance that was induced in P acnes treated with erythromycin.30

Silica Beads and Corn Starch

Cetaphil DermaControl Moisturizer SPF 30 also contains silica beads and corn starch, which are sebum absorbent. Silica beads and corn starch have been shown not only to significantly reduce sebum, but also to reduce “facial shine,” an oily sheen of sebum that becomes pronounced on the faces of AV patients.4
A study evaluated the potential of Cetaphil DermaControl Moisturizer SPF 30 to mitigate sebum and “facial shine.”4 After application of Cetaphil DermaControl Moisturizer SPF 30 to the faces of AV patients, sebum excretion rates were measured using a Sebumeter, and Sebutape was also used to collect sebum released from infundibular reservoirs.4 The investigators found that “facial shine” and sebum levels were significantly reduced within hours of Cetaphil DermaControl Moisturizer SPF 30 application, and the effect lasted for up to 8 hours.4
The reduction of sebum production and “facial shine” is essential in the management of AV patients’ psychosocial morbiditites because “facial shine” can be emotionally disconcerting to AV patients. Moreover, by incorporating sebosuppressive and sebum- absorbent ingredients (ie, zinc gluconate, silica beads, and corn starch), and also Ceramide Technology, Cetaphil Derma- Control Moisturizer SPF 30 is a formulation that reduces “oil” or sebum while simultaneously preventing TEWL and enhancing skin hydration.

CONCLUSION

Cetaphil DermaControl Moisturizer SPF 30 provides broad spectrum photoprotection while improving moisturization, and is designed for patients with acne-prone skin. The key ingredients of the photoprotecting moisturizer are unique and specifically designed to balance the effects of acne treatments while not irritating the skin or exacerbating acne.

DISCLOSURES

Dr. Kircik has served as an advisor, investigator, consultant, and speaker for Allergan, Bayer, Galderma, Johnson & Johnson, Promius Pharma, Quinnova, Stiefel/GSK, LeoPharma, Taro, Valeant, and Warner-Chilcott.
Dr. Bowe has served as a consultant, advisory board participant, and/or speaker for Allergan, Bayer, Galderma, Johnson and Johnson, L’Oreal USA, Onset Therapeutics, and Proctor and Gamble.

REFERENCES

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