SUPPLEMENT INDIVIDUAL ARTICLES: Update on Truncal Acne: A Review of Treatments for a Neglected Disease and the Re-Emergence of Tazarotene

December 2022 | Volume 21 | Issue 12 | SF3446185 | Copyright © December 2022


Published online November 30, 2022

Naiem T. Issa MD PhDa, Zoe Draelos MDb, Emil Tanghetti MDc, Leon H. Kircik MDd

aForefront Dermatology, Vienna, VA
bDermatology Consulting Services, PLLC, High Point, NC
cCenter for Dermatology and Laser Surgery, Sacramento, CA
dIcahn School of Medicine at Mount Sinai, New York, NY; Indiana University Medical Center, Indianapolis, IN;
Physicians Skin Care, PLLC Louisville, KY; DermResearch, PLLC Louisville, KY; Skin Sciences, PLLC Louisville, KY

51. Del Duca E, Manfredini M, Petrini N, et al. Daylight photodynamic therapy with 5-aminolevulinic acid 5% gel for the treatment of mild-to-moderate inflammatory acne. Ital J Dermatol Venereol. 2021;156(1): 46–50. doi: 10.23736/S2784-8671.19.06392-2
52. Fabbrocini G, Cacciapuoti S, De Vita V, Fardella N, Pastore F, Monfrecola G. The effect of aminolevulinic acid photodynamic therapy on microcomedones and macrocomedones. Dermatology. 2009;219(4):322-328. doi: 10.1159/000252854
53. Moftah NH, Ibrahim SM, Wahba NH. Intense pulsed light versus photodynamic therapy using liposomal methylene blue gel for the treatment of truncal acne vulgaris: a comparative randomized split body study. Arch Dermatol Res. 2016;308(4):263-268. doi: 10.1007/ s00403-016-1639-6
54. Shaaban D, Abdel-Samad Z, El-Khalawany M. Photodynamic therapy with intralesional 5-aminolevulinic acid and intense pulsed light versus intense pulsed light alone in the treatment of acne vulgaris: a comparative study: Photodynamic therapy in acne vulgaris. Dermatol Ther. 2012;25(1):86-91. doi: 10.1111/j.1529- 8019.2012.01427. 
55. Piccolo D, Kostaki D, Dianzani C, Crisman G, Conforti C. Effective intense pulsed light protocol in the treatment of moderate to severe acne vulgaris of the chest and back. J Clin Aesthet Dermatol. 2022;15(3):22-25.
56. Schulte BC, Wu W, Rosen T. Azelaic acid: evidence-based update on mechanism of action and clinical application. J Drugs Dermatol. 2015;14(9):964-968.
57. Hoffman LK, Del Rosso JQ, Kircik LH. The efficacy and safety of azelaic acid 15% foam in the treatment of truncal acne vulgaris. J Drugs Dermatol. 2017;16(6):534-538.
58. Kainz JT, Berghammer G, Auer-Grumbach P, et al. Azelaic acid 20 % cream: effects on quality of life and disease severity in adult female acne patients: Azelaic acid 20 % cream in adult female acne patients. JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 2016;14(12):1249-1259. doi: 10.1111/ddg.12889
59. Zaenglein AL, Pathy AL, Schlosser BJ, et al. Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology. 2016;74(5):945-973.e33. doi: 10.1016/j. jaad.2015.12.037
60. Ghaoui N, Hanna E, Abbas O, Kibbi A, Kurban M. Update on the use of dapsone in dermatology. Int J Dermatol. 2020;59(7):787- 795. doi: 10.1111/ijd.14761
61. Stotland M, Shalita AR, Kissling RF. Dapsone 5% gel: a review of its efficacy and safety in the treatment of acne vulgaris. American Journal of Clinical Dermatology. 2009;10(4):221-227. doi: 10.2165/00128071-200910040-00002
62. Al-Salama ZT, Deeks ED. Dapsone 7. 5% gel: a review in acne vulgaris. Am J Clin Dermatol. 2017;18(1):139-145. doi: 10.1007/ s40257-016-0242-0
63. Del Rosso JQ, Kircik L, Tanghetti E. Management of truncal acne vulgaris with topical dapsone 7. 5% gel. J Clin Aesthet Dermatol. 2018;11(8):45-50.
64. Słopień R, Milewska E, Rynio P, Męczekalski B. Use of oral contraceptives for management of acne vulgaris and hirsutism in women of reproductive and late reproductive age. Prz Menopauzalny. 2018;17(1):1-4. doi: 10.5114/pm.2018.74895
65. Palli MBA, Reyes-Habito CM, Lima XT, Kimball AB. A single-center, randomized double-blind, parallel-group study to examine the safety and efficacy of 3mg drospirenone/0.02 mg ethinyl estradiol compared with placebo in the treatment of moderate truncal acne vulgaris. J Drugs Dermatol. 2013;12(6):633-637.
66. Charny JW, Choi JK, James WD. Spironolactone for the treatment of acne in women, a retrospective study of 110 patients. International Journal of Women’s Dermatology. 2017;3(2):111-115. doi: 10.1016/j.ijwd.2016.12.002
67. Garg V, Choi JK, James WD, Barbieri JS. Long-term use of spironolactone for acne in women: A case series of 403 patients. Journal of the American Academy of Dermatology. 2021;84(5):1348- 1355. doi: 10.1016/j.jaad.2020.12.071
68. Dhillon S. Clascoterone: first approval. Drugs. 2020;80(16):1745- 1750. doi: 10.1007/s40265-020-01417-6
69. Hebert A, Thiboutot D, Stein Gold L, et al. Efficacy and safety of topical clascoterone cream, 1%, for treatment in patients with facial acne: two phase 3 randomized clinical trials. JAMA Dermatol. 2020;156(6):621. doi: 10.1001/jamadermatol.2020.0465
70. Eichenfield L, Hebert A, Gold LS, et al. Open-label, long-term extension study to evaluate the safety of clascoterone (CB-03-01) cream, 1% twice daily, in patients with acne vulgaris. Journal of the American Academy of Dermatology. 2020;83(2):477-485. doi: 10.1016/j.jaad.2020.04.087
71. Zhanel G, Critchley I, Lin LY, Alvandi N. Microbiological profile of sarecycline, a novel targeted spectrum tetracycline for the treatment of acne vulgaris. Antimicrob Agents Chemother. 2019;63(1):e01297-18. doi: 10.1128/AAC.01297-18
72. Moura IB, Grada A, Spittal W, et al. Profiling the effects of systemic antibiotics for acne, including the narrow-spectrum antibiotic sarecycline, on the human gut microbiota. Front Microbiol. 2022;13:901911. doi: 10.3389/fmicb.2022.901911
73. Moore A, Green LJ, Bruce S, et al. Once-daily oral sarecycline 1. 5 mg/kg/day is effective for moderate to severe acne vulgaris: results from two identically designed, phase 3, randomized, double-blind clinical trials. J Drugs Dermatol. 2018;17(9):987-996.
74. Del Rosso JQ, Stein Gold L, Baldwin H, et al. Management of truncal acne with oral sarecycline: pooled results from two phase-3 clinical trials. J Drugs Dermatol. 2021;20(6):634-640. doi: 10.36849/ JDD.2021.6204
75. DeRuiter J., Holston P. L. Trifarotene (Aklief, Galderma). 2020;45(10):26–33.
76. Eichenfield L, Kwong P, Lee S, Krowchuk D, Arekapudi K, Hebert A. Advances in topical management of adolescent facial and truncal acne: a phase 3 pooled analysis of safety and efficacy of trifarotene 0. 005% cream. JDD. 2022;21(6):582-586. doi: 10.36849/JDD.6778
77. Blume‐Peytavi U, Fowler J, Kemény L, et al. Long‐term safety and efficacy of trifarotene 50 μg/g cream, a first‐in‐class RAR ‐γ selective topical retinoid, in patients with moderate facial and truncal acne. J Eur Acad Dermatol Venereol. 2020;34(1):166-173. doi: 10.1111/jdv.15794
78. Del Rosso JQ, Tanghetti E. A status report on topical tazarotene in the management of acne vulgaris. J Drugs Dermatol. 2013;12(3):s53-58.