SUPPLEMENT INDIVIDUAL ARTICLES: Update on Truncal Acne: A Review of Treatments for a Neglected Disease and the Re-Emergence of Tazarotene

December 2022 | Volume 21 | Issue 12 | SF3446185 | Copyright © December 2022


Published online November 30, 2022

Naiem T. Issa MD PhDa, Zoe Draelos MDb, Emil Tanghetti MDc, Leon H. Kircik MDd

aForefront Dermatology, Vienna, VA
bDermatology Consulting Services, PLLC, High Point, NC
cCenter for Dermatology and Laser Surgery, Sacramento, CA
dIcahn School of Medicine at Mount Sinai, New York, NY; Indiana University Medical Center, Indianapolis, IN;
Physicians Skin Care, PLLC Louisville, KY; DermResearch, PLLC Louisville, KY; Skin Sciences, PLLC Louisville, KY

Abstract
Acne vulgaris of the trunk carries with it a major psychosocial impact and an unmet need for adequate management. Approximately 50% of patients with facial acne also exhibit involvement of the back, chest, and/or upper arms. The trunk poses a therapeutic challenge given its occlusion by clothing, the tendency for mechanical rubbing, a sebum physiology that differs from the face, as well as the fact that there is a large surface area for topical therapies to cover. Furthermore, truncal acne is underreported for a variety of reasons such as cultural barriers, sentiments of embarrassment, and prioritization of facial acne. To date, few medications have been studied specifically for truncal acne. In this article, an updated review of truncal acne and available therapies is provided. The most recent evidence for tazarotene, a third-generation retinoid previously approved for psoriasis and facial acne vulgaris over two decades ago, is also reviewed and compared to trifarotene, a fourth-generation retinoid that is the only approved tropical retinoid for both facial and truncal acne.

J Drugs Dermatol. 2022;21:12(Suppl):s5-14.

INTRODUCTION

Acne vulgaris is among the most common skin diseases worldwide with a prevalence estimated to be 9.4% of the global population.1 The psychosocial impact of acne is significant and can negatively impact quality of life (QoL), especially in adolescents and teens.2 Its pathogenesis has been well established, and a variety of treatments have been developed including numerous medications and procedures such as chemical peels and lasers. Prompt initiation of treatment that is appropriate for the severity of disease is critical to avoid disfiguring scars and pigmentary changes as well as psychological morbidity.

While facial acne has been extensively addressed in the medical literature, truncal acne has been given little emphasis.3 Truncal acne poses multiple challenges both from therapeutic and quality-of-life perspectives. The larger surface area of involvement on the trunk relative to the face lends difficulty to topical treatments with respect to dosing, formulations, ease of application, and tolerability of adverse effects such as irritation due to being under clothing - all which lead to reduced compliance. It is also underreported as many patients tend not to voluntarily report their truncal acne, likely resulting in undertreatment and continued disease burden. There have also