The mean pain of all 3 treatments as measured using VAS was 4.0 cm out of 10.0 cm, which correlates to "mild pain". There was no statistically significant difference in pain VAS scores between the 3 treatment visits (P=0.67), however, pain did on average decrease from 4.3 at the first treatment to 3.8 at the second treatment and to 3.5 at the third treatment.
Blinded Review of Photographs
A series of before and after photos were included for blinded review, using a global aesthetic improvement scale (GAIS), with -3=very much worse and +3=very much improved; with 1=being improved and 2=being much improved (Figure 4, 5). The GAIS incorporates characteristics such as wrinkling and pigmentation
