Quantifying Depth of Injection of Hyaluronic Acid in the Dermis: Data from Clinical, Laboratory, and Ultrasound Settings

April 2016 | Volume 15 | Issue 4 | Original Article | 483 | Copyright © April 2016


Patrick Micheels MD,a Stéphanie Besse MD,b Didier Sarazin MD,c Anne Grand Vincent MD,d
Natalia Portnova MD,e Marva Safa Diana MDf

a Private practice, Geneva, Switzerland
b Private radiographic imaging, Institut MedImage, Geneva, Switzerland
c Laboratoire Viollier-Weintraub, Geneva, Switzerland
d Private practice, Paris, France
e Private practice, Riga, Latvia
f Private practice, Neuchâtel, Switzerland

table 2
Allergan-Cornéal (Pringy, France)]; and Belotero® [(BEL) Balance, Merz Pharmaceuticals, GmbH. (Frankfurt, Germany)]/Esthélis® Basic-Antéis S.A. (Geneva, Switzerland)].
Needles
In the studies described here, only Becton-Dickinson needles were used, specifically BD® Microlance 30 G ½ in. (0.3 X 13mm) [lot n° 1009 20 Exp: 2015-08]. These needles have a diameter of 0.3 mm, a total length of 13 mm, and a bevel length of 1 mm.
Ultrasound imaging
The device for the different ultrasound studies12,13 was the General Electric logiQ E9® (General Electric Company, Fairfield, CT) with probe Hockey stick L8 18i®, 17 mega-Herz. An interface SonarAid GeistlichPharma® [lot 100353], (Geistlich Pharma AG, Wolhusen, Switzerland), was placed over the treated area to obtain a clearer definition of the US image. This SonarAid device, placed by investigators, ensures an echoless, undisturbed picture.
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