Evaluation of the Physician Global Assessment and Body Surface Area Composite Tool for Assessing Psoriasis Response to Apremilast Therapy: Results from ESTEEM 1 and ESTEEM 2

February 2017 | Volume 16 | Issue 2 | Original Article | 147 | Copyright © February 2017


Kristina C. Duffin MD MS,a Kim A. Papp MD PhD,b Jerry Bagel MD,c Eugenia Levi PharmD BCPS,d Rongdean Chen PhD,d and Alice B. Gottlieb MD PhDe

aUniversity of Utah, Salt Lake City, UT bProbity Medical Research and K Papp Clinical Research, Waterloo, ON, Canada cPsoriasis Treatment Center of Central New Jersey, East Windsor, NJ dCelgene Corporation, Summit, NJ eTufts University School of Medicine, Boston, MA

Figure 3psoriasis disease severity in patients with mild to moderate disease (ie, median BSA involvement of 3.0%).5 A responsiveness to change analysis indicated that PGAxBSA and PASI had similar abilities to capture changes in disease severity. However, response to therapy could not be determined in this study due to the different treatments used in the registry. Similar findings were reported in a retrospective multicenter study using data from the Dermatology Clinical Effectiveness Research Network (DCERN), a consortium of private and academic centers of dermatologists in the United States, that included patients with