Efficacy and Tolerability of a Novel Topical Treatment for Neck: A Randomized, Double-blind, Regimen-Controlled Study

February 2021 | Volume 20 | Issue 2 | Original Article | 184 | Copyright © February 2021


Published online January 19, 2021

Elizabeth T. Makino BS CCRA MBA,a Kuniko Kadoya PhD,a Robin Chung MS,a Lily Jiang PhD,b Mouna Mikati PhD,a Rahul C. Mehta PhDa

aSkinMedica - Allergan Aesthetics, an AbbVie Company, Irvine, CA
bSGS Stephens Inc., Richardson,TX

cellular components and an exacerbated intrinsic aging process.16,17 NCC treatment resulted in upregulation of various genes related to proteasome assembly and function (POMP, PSMB5, PSMB6), different stages of autophagy (ATG5, ATG7, ATG12, BECN1), and protein folding and stabilization (HSPA8) suggesting that NCC helps maintain proteostasis and mitigate intrinsic aging processes to support a healthier and more youthful appearance of the neck and décolletage.

CONCLUSION

Rejuvenation of neck skin requires a differentiated approach that is tailored to the neck’s specific characteristics. Designed to address the signs of skin aging of the neck and décolletage, NCC significantly improved skin laxity/sagging, firmness and elasticity of the neck, as well as overall appearance and skin quality of both the neck and décolletage area. The clinical findings from this double-blind, regimen-controlled study were corroborated by in vitro analysis in human 3D skin models demonstrating stimulation of neocollagenesis and neoelastogenesis as well as support of cellular proteostasis, providing insights on possible mechanisms of action for the observed clinical outcomes.

DISCLOSURES

Financial support for these studies were provided by Allergan Aesthetics, Inc., an AbbVie Company. Ms. Makino, Dr. Kadoya, Ms. Chung, Dr. Mikati, and Dr. Mehta are employees of Allergan Aesthetics, Inc., an AbbVie Company.

ACKNOWLEDGMENT

The authors gratefully acknowledge Phillip Lai for technical support.

Data Sharing
AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual, and trial-level data (analysis data sets), as well as other information (e.g. protocols and clinical study reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.

This clinical trial data can be requested by any qualified researchers who engage in rigorous, independent scientific research, and will be provided following review and approval of a research proposal and statistical analysis plan and execution of a data sharing agreement. Data requests can be submitted at any time and the data will be accessible for 12 months, with possible extensions considered. For more information on the process, or to submit a request, visit: https://www.abbvie.com/our-science/clinical-trials/clinical-trials-data-and-information-sharing/data-and-information-sharing-with-qualified-researchers.html.

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AUTHOR CORRESPONDENCE

Mouna Mikati PhD mouna.mikati@allergan.com
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