Efficacy and Tolerability of a Novel Topical Treatment for Neck: A Randomized, Double-blind, Regimen-Controlled Study

February 2021 | Volume 20 | Issue 2 | Original Article | 184 | Copyright © February 2021


Published online January 19, 2021

Elizabeth T. Makino BS CCRA MBA,a Kuniko Kadoya PhD,a Robin Chung MS,a Lily Jiang PhD,b Mouna Mikati PhD,a Rahul C. Mehta PhDa

aSkinMedica - Allergan Aesthetics, an AbbVie Company, Irvine, CA
bSGS Stephens Inc., Richardson,TX

NCC provided significant improvements in neck laxity/sagging at 8 weeks with continued improvements through week 12, compared to control (all P≤0.006; Wilcoxon rank sum test) and compared to baseline (all P<0.001; Wilcoxon signed rank test). The control group only showed significance at week 12 compared to baseline in laxity/sagging (P=0.031; Wilcoxon signed rank test; Figure 3).

NCC also provided significant improvements in fine lines/ wrinkles, tactile roughness, and crepiness at all follow-up visits and in coarse lines/wrinkles, hyperpigmentation, skin tone evenness, radiance, and overall skin texture at weeks 8 and 12, compared to baseline (all P≤0.035; Wilcoxon signed rank test; Figure 4).