INDIVIDUAL ARTICLE: Pediatric Atopic Dermatitis Patient Cases Integrating Ceramides-Containing Cleansers and Moisturizers into Prescription Treatment and Maintenance Approaches

December 2023 | Volume 22 | Issue 12 | SF389716s3 | Copyright © December 2023


Published online November 28, 2023

Lawrence A Schachner MD FAAD FAAPa, Anneke Andriessen PhDb, Madelyn Dones MD FAAPc, Mercedes E Gonzalez MD FAADd, Linda Keller MD FAAPe, Karan Lal MD MS FAADf, Peter Lio MD FAADg, Ayleen Pinera-Llano MD FAAPh, Latanya Benjamin MD FAAD FAAPi

aDivision of Pediatric Dermatology, Department of Dermatology and Cutaneous Surgery, Department of Pediatrics, Leonard M. Miller School of Medicine, University of Miami, FL
bRadboud UMC, Nijmegen and Andriessen Consultants, Malden, The Netherlands
cBaptist Health Hospital, Nicklaus Childrens’Hosptital, Miami, FL
dMedical Director, Pediatric Skin Research, Assistant Professor Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery at the University of Miami Miller School of Medicine Miami, FL
eBaptist Health Baptist Hospital, Baptist Health South Miami Hospital, Miami, FL
fSchweiger Dermatology Group, New York, NY
gClinical Assistant Professor of Dermatology & Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL
hKing Bay Pediatrics, Maimi, FL, General Pediatrics, Nicklaus Children's Hospital, Miami, FL
iAssociate Professor of Pediatric Dermatology, Department of Women's and Children's Health, Florida Atlantic University, Boca Raton, FL

Abstract
Introduction: Atopic dermatitis (AD) is a common, chronic recurrent disorder typically starting in infancy and early childhood and associated with pruritus and genetic predisposition. Daily use of moisturizers that contain lipids such as ceramides (CER) reduces the rate of AD flares and the need for topical steroid treatment.

A pediatric AD case series is presented to educate healthcare providers treating children with AD to tailor AD prescription therapy, skincare, and maintenance treatment to improve patient outcomes.

Methods: The advisors discussed 15 pediatric AD patient cases and agreed to select six patients covering various presentations of pediatric AD, patient ages, and skin types.

Results: The advisors discussed why they selected the case, previous treatment, type of prevention and education provided, skincare as mono or adjunctive treatment, prescription and nonprescription therapy and maintenance treatment, and clinical pearls. Two patient cases discuss infants with early onset AD who benefitted from frequent and ongoing ceramide-containing skincare. The other four patient cases present children aged 2 to 9 years who benefitted from skincare as an adjunct to topical corticosteroid therapy.

Conclusion: Sharing best practices in AD therapy and maintenance treatment for pediatric AD patients may support healthcare providers treating newborns, infants, and children to improve clinical outcomes. Consistent skincare use with ceramide-containing cleansers and moisturizers as mono or adjunctive to prescription treatment promoted a healthy skin barrier.

J Drugs Dermatol. 2023;22:12(Suppl 1):s3-14.

INTRODUCTION

Atopic dermatitis (AD) is a common, chronicrecurrent disorder associated with pruritus and genetic predisposition diagnosed at a mean age of 1.6 years.1,2 The first AD flares frequently occur in infancy and may recur or persist during childhood and adulthood.1-3 Persistent severe AD is somewhat more associated with the female sex and onset after two years of age.3 Guidelines and algorithms for treating AD in pediatric and adult patients have recommended skincare using cleansers and moisturizers as monotherapy in mild to moderate flares or as an adjunct to prescription and nonprescription AD treatment and maintenance.4-6

Ongoing, daily use of moisturizers that contain lipids such as ceramides (CER) reduces the rate of AD flares and the need for topical steroid treatment.7,8

A pediatric AD case series is presented to educate healthcare providers treating newborns, infants, and children with AD to tailor AD prescription and nonprescription therapy, skincare, and maintenance treatment to improve patient outcomes. 

MATERIALS AND METHODS

A panel (advisors) of 8 pediatric dermatologists, dermatologists, and pediatricians who treat pediatric AD patients reported on clinical cases from their practice. Evidence from the literature and the panels' expert opinions, experiences, and key insights reflect the advisors' use of CER-containing skincare as monotherapy or as an adjunct to prescription treatment for pediatric patients with AD. In addition, a review of findings reflects real-world clinical use of CER-containing skincare and how patients can benefit from its treatment, ie, "what experienced specialists are doing for their pediatric AD patients". 

During the February 11, 2023, meeting, each advisor presented pediatric AD patient cases from their practice. A CER-containing skincare regime was used as adjunctive treatment or monotherapy for pediatric AD patients. The advisors gathered patient case information on gender, age, Fitzpatrick skin phototype,9 AD history, presentation, a treatment plan summary, results, and key learning points. The self-recorded skin type used a Fitzpatrick score from phototype I up to Type VI (Type I [scores 0-6] always burns, never tans, Type II [scores 7-13] usually burns, tans minimally, Type III [scores 14-20] sometimes mild burn, tans uniformly [golden honey or olive], Type IV [scores 21-27] burns slightly, always tans well, Type V [scores 28-34] very rarely burns, tans very easy [dark brown], and Type VI [scores 35-36] never burns [richly pigmented]).9

Of the 15 cases presented during the meeting, the advisors agreed to select six patient cases covering various ages and skin types, including pediatric patients with richly pigmented skin, and give a logical flow from infants to children. 

Pediatric Atopic Dermatitis Patient Case Series  

The advisors discussed why they selected the case, previous treatment, type of prevention and education provided, skincare as mono or adjunctive treatment, prescription and nonprescription therapy