Efficacy of a Skin Condition-Adapted Solution for Xerosis and Itch Relief Associated With Aging

November 2016 | Volume 15 | Issue 11 | Supplement Individual Articles | 91 | Copyright © November 2016

Ramsin Joseph Yadgar BS,a and Adam J. Friedman MDa,b

aThe George Washington University, School of Medicine and Health Sciences,Washington, DC bDepartment of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY

Figure 2 as a control. Treatment parameters were individually adjusted according to the Fitzpatrick skin type of each subject: for those who are skin type III, a 6mm diffractive lens array with a fluence of 0.71J/cm2 delivered at 2.5 to 5 Hz was used; for skin type IV patients, an 8mm diffractive lens array with a fluence of 0.4J/cm2 delivered at 2.5 to 5 Hz was used. An average of 1500 pulses was delivered on the treated side of the face for each subject in one treatment session. Typically, two to three passes with a 10-20% overlap between each pulse were required to achieve the clinical endpoint of moderate erythema. Following each treatment session, a cooling mask was immediately applied to provide a soothing effect, followed by the use of moisturizer. Sun block was also advised. Subjects were followed up for two months after the completion of all four treatment sessions.

Evaluation of Efficacy and Complications

Assessment of facial photoaging was conducted by two blinded independent dermatologists who were not involved in the enrollment, treatment, or study visit. Digital photographs were taken from different angles at baseline, each treatment visit, and follow-up time points. Based on these digital photographs, severity of facial photoaging was then assessed based on two scales, a 5-point Global Photoaging Scale (GPS) by Dover et al.16 and a 6/8-point Asian Photographic Scale (APS) described by Chuang et al.17 In addition, a 10-point Visual Analog Scale (VAS) was also used to evaluate the pain associated with the treatment immediately post treatment. Post-treatment erythema, edema, pigmentary changes, and other anticipated side effects were also documented at each visit.

Statistical Analysis

The Wilcoxon signed rank test was used to compare the scores of GPS and APS of each side of the face between baseline and 2-month follow-up visit. Meanwhile, differences of GPS on the same side of the face among all time points were determined by the Friedman test. The VAS of pain was also analyzed. Statistical analysis was conducted by IBM SPSS version 16.0 (IBM Corporation, Somers, NY). The level of significance was defined as P<0.05.


Ten female subjects were enrolled in the study and all participated to completion. The mean age was 45.70±7.94. Five subjects were categorized as Fitzpatrick skin type III and the