Efficacy of a Skin Condition-Adapted Solution for Xerosis and Itch Relief Associated With Aging

laser toning by shortening the pulse to the picosecond domain. This type of treatment, called “Fractional Pico Toning” has been gaining much popularity among patients with mild-to-moderate degree of photoaging. It involves multiple passes of the diffractive lens array over the targeted tissue which helps to clear the mild-moderate photoaging as well as aid in textural improvements. There is however, only limited clinical research that had been done in Asians. The present study aims to evaluate the efficacy of the picosecond alexandrite laser with a diffractive lens array for the treatment of facial photoaging in Chinese patients.

This is a prospective, evaluator-blinded, open-label, split-face study conducted in compliance with the Declaration of Helsinki. Institutional Review Board (IRB) approval was granted by the local medical research ethics committee. Ten Subjects (10 females) were enrolled in this study, age 30–55, with Fitzpatrick skin type III–IV, and presenting with symmetrical evidence of facial photoaging with a baseline at least grade 2 out of a 5-point global photoaging scale described by Dover et al.¹⁶ The exclusion criteria includes a alhistory of resurfacing procedures within last two years, recent severe sun exposure, the use of oral retinoid or other photosensitive medications, active skin infections or inflammatory disorders, history of keloid and hypertrophic scar, severe systemic conditions, pregnancy, and lactation. Informed consents were obtained from the subjects before they were enrolled.

The study was designed to evaluate the efficacy of the picosecond alexandrite laser with a diffractive lens array for the treatment of facial photoaging in Chinese patients. Subjects received a total of four sessions of laser treatments at a two-week interval. Prior to each treatment session, subjects were requested to have their faces gently cleansed and patted dry. No topical anesthetic was applied. The 755nm picosecond alexandrite laser (Picosure, Cynosure, MA) with a diffractive lens array (Focus Optic) was utilized in all treatment sessions. The intervention was conducted in a split-face manner at each session: the right side of the face received treatment from the 755nm picosecond alexandrite laser with a diffractive lens array, and the left side of the face received no intervention acting