of genes that are associated with tissue remodeling (eg, Serpin E1, MMP3) as well as a downregulation of differentiation markers (eg, KRT1, FLG) (Figures 2C and 2D), reflecting the enhanced cell proliferation in the epidermal layer of the 3D skin model. Moreover, qRT-PCR analysis confirmed the stimulating effects of the combined treatment on Serpin E1 (Figure 2E).
DISCUSSION
This study aimed at understanding more precisely the
biological effects of HA-based fillers, their combination with
laser treatment and their differences to PLLA-based fillers. Our
data show enhancing effects of dermal fillers on epidermal