are regimen, the clinically graded signs of aging, including fine lines, pore size, lack of clarity/radiance, mottled pigmentation, wrinkles, and laxity, significantly improved. This unique retinol peel and homecare regimen provided benefits to acne and melasma as well. Subject self-assessment provided further support to the clinical grading. Obvious benefits and tolerability of the peels and homecare are further demonstrated through digital photography. The retinol peel was well tolerated under physician direction when applied and left on for 8 hours or overnight (>8 hours) across a range of skin types and conditions. Minimal irritation was observed during the peel procedure, though the physician must manage patient expectations for peeling and redness in the days following application of the peel. Peeling did not occur immediately, but usually by day 3 and resolved within approximately 1 week. Gentle, restorative post-procedure PHA products can be used post-peel until the skin returns to normal and thereafter to complement benefits of the peel. These results demonstrate that the 3% retinol superficial peel is well tolerated in all skin types and is an effective method of delivering clinical improvements in subjects with photodamage, as well as acne and hyperpigmentation or melasma.
Physicians have many modalities available in their armamentarium, and chemical peels continue to be a mainstay of therapy. This unique, high-strength retinol peel provides a new tool for the physician and their patient, particularly to those desiring a visual cue, or those without objection to the potential for obvious peeling. While still falling under the category of a superficial chemical peel the proven benefits of retinol are available with a high concentration of retinol, far above that available to a consumer. Additionally, compatibility of the retinol peel was shown in a variety of populations that can be difficult to treat and may be prone to post-inflammatory hyperpigmentation, such as patients with melasma or Fitzpatrick skin types IV-VI. The retinol peel provides a versatile option to the physician to offer to all patients desiring superficial skin rejuvenation.
Physicians have many modalities available in their armamentarium, and chemical peels continue to be a mainstay of therapy. This unique, high-strength retinol peel provides a new tool for the physician and their patient, particularly to those desiring a visual cue, or those without objection to the potential for obvious peeling. While still falling under the category of a superficial chemical peel the proven benefits of retinol are available with a high concentration of retinol, far above that available to a consumer. Additionally, compatibility of the retinol peel was shown in a variety of populations that can be difficult to treat and may be prone to post-inflammatory hyperpigmentation, such as patients with melasma or Fitzpatrick skin types IV-VI. The retinol peel provides a versatile option to the physician to offer to all patients desiring superficial skin rejuvenation.
DISCLOSURES
Ms. Edison, Ms. John, and Ms. Green are employees of NeoStrata
Company, Inc. Dr. Sadick served as the study investigator and
has been a speaker for NeoStrata Company, Inc. Ms. Bohnert
was an employee of Sadick Research Group LLC and is now at
Celgene.
REFERENCES
1. 2018 National Plastic Surgery Statistics. American Society of Plastic Surgeons. https://www.plasticsurgery.org/documents/News/Statistics/2018/ plastic-surgery-statistics-report-2018.pdf. Accessed May 17, 2019.
2. Vemula S, Maymone M, Secemsky E, et al. Assessing the safety of superficial chemical peels in darker skin: A retrospective study. J Am Acad Dermatol. 2018;79(3):508-513.
3. Hexsel D, Arellano I, Rendon M. Ethnic considerations in the treatment of Hispanic and Latin-American patients with hyperpigmentation. Br J Dermatol. 2006;1:7-12.
4. Yeh L, Bonati LM, Silverberg NB. Topical retinoids for acne. Semin Cutan Med Surg. 2016;35(2):50-6.
5. Tucker-Samaras S, Zedayko T, Cole C, et al. A stabilized 0.1% retinol facial moisturizer improves the appearance of photodamaged skin in an eight week, double-blind, vehicle-controlled study. J Drugs Dermatol. 2009;8(10):932-6.
6. Kafi R, Kwak HS, Schumacher WE, et al. Improvement of naturally aged skin with vitamin A (retinol). Arch Dermatol. 2007;143:606-612.
7. Kang S, Duell EA, Fisher GJ, et al. Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. J Invest Dermatol. 1995;105:549-556.
8. Bulengo-Ransby SM, Griffiths CE, Kimbrough-Green CK, et al. Topical tretinoin (retinoic acid) therapy for hyperpigmented lesions caused by inflammation of the skin in black patients. N Engl J Med. 1993;328(20):1438-43.
9. Farris PK, Edison BL, Weinkauf RL, et al. A novel, volumizing cosmetic formulation significantly improves the appearance of target glabellar lines, nasolabial folds, and crow’s feet in a double-blind, vehicle controlled clinical trial. J Drugs Dermatol. 2014;13(1):41-6.
10. Khusial R, Conte J, Santhanam U. A novel mode of action to stimulate collagen production in aged skin cells. Glycobiology. 2012;22:1645.
11. Schlessinger J, Green B, Edison BL, et al. A firming neck cream containing n-acetyl glucosamine significantly improves signs of aging on the challenging neck and decolletage. J Drugs Dermatol. 2016;15(1):47-52.
2. Vemula S, Maymone M, Secemsky E, et al. Assessing the safety of superficial chemical peels in darker skin: A retrospective study. J Am Acad Dermatol. 2018;79(3):508-513.
3. Hexsel D, Arellano I, Rendon M. Ethnic considerations in the treatment of Hispanic and Latin-American patients with hyperpigmentation. Br J Dermatol. 2006;1:7-12.
4. Yeh L, Bonati LM, Silverberg NB. Topical retinoids for acne. Semin Cutan Med Surg. 2016;35(2):50-6.
5. Tucker-Samaras S, Zedayko T, Cole C, et al. A stabilized 0.1% retinol facial moisturizer improves the appearance of photodamaged skin in an eight week, double-blind, vehicle-controlled study. J Drugs Dermatol. 2009;8(10):932-6.
6. Kafi R, Kwak HS, Schumacher WE, et al. Improvement of naturally aged skin with vitamin A (retinol). Arch Dermatol. 2007;143:606-612.
7. Kang S, Duell EA, Fisher GJ, et al. Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. J Invest Dermatol. 1995;105:549-556.
8. Bulengo-Ransby SM, Griffiths CE, Kimbrough-Green CK, et al. Topical tretinoin (retinoic acid) therapy for hyperpigmented lesions caused by inflammation of the skin in black patients. N Engl J Med. 1993;328(20):1438-43.
9. Farris PK, Edison BL, Weinkauf RL, et al. A novel, volumizing cosmetic formulation significantly improves the appearance of target glabellar lines, nasolabial folds, and crow’s feet in a double-blind, vehicle controlled clinical trial. J Drugs Dermatol. 2014;13(1):41-6.
10. Khusial R, Conte J, Santhanam U. A novel mode of action to stimulate collagen production in aged skin cells. Glycobiology. 2012;22:1645.
11. Schlessinger J, Green B, Edison BL, et al. A firming neck cream containing n-acetyl glucosamine significantly improves signs of aging on the challenging neck and decolletage. J Drugs Dermatol. 2016;15(1):47-52.
AUTHOR CORRESPONDENCE
Brenda L. Edison bedison@its.jnj.com
