day 7 (Figure 1). Subjective irritation including up to moderate stinging/burning, tightness/dryness, and skin sensitivity was also reported at day 3 and diminished by day 7 (Table 2). One subject experienced an adverse event consisting of eye area irritation (puffiness/swelling, redness, itching) after the peel. She continued on the study avoiding application too close to the eye.
Statistical analysis was conducted for dermatologist graded aging parameters in the Photodamage group; no statistical analysis of efficacy parameters was conducted for the case studies included in the Melasma group, Skin of Color group, or Acne Subgroup based on the small population sizes. All dermatologist graded aging parameters were significantly improved after 4 peels in the Photodamage group, P<0.05. Additionally, overall photodamage significantly improved after 1 peel, and fine lines and pore size significantly improved after 3 peels, P≤0.05 (Figure 2). Although statistical analysis was not performed for the case study groups including the Skin of Color group, Melasma group, and Acne Subgroup, all dermatologist graded photodamage parameters and overall acne severity decreased over the course of the study (Figure 3). Digital photography demonstrated obvious antiaging effects (Figure 4), as well as benefits to acne (Figure 5) and melasma (Figure 6). Self-assessed aging parameters were improved, providing subjective support of the clinical data (Table 3, Figure 7). The PHA/Bionic supportive home care products were well-tolerated when used in conjunction with the retinol peel. The 3% retinol peel, in conjunction with a homecare regimen, was well tolerated in subjects with photodamage, acne, hyperpigmentation/ melasma, and skin of color (Fitzpatrick skin types IV-VI), and demonstrated visible improvements in antiaging parameters, acne, and melasma.
Statistical analysis was conducted for dermatologist graded aging parameters in the Photodamage group; no statistical analysis of efficacy parameters was conducted for the case studies included in the Melasma group, Skin of Color group, or Acne Subgroup based on the small population sizes. All dermatologist graded aging parameters were significantly improved after 4 peels in the Photodamage group, P<0.05. Additionally, overall photodamage significantly improved after 1 peel, and fine lines and pore size significantly improved after 3 peels, P≤0.05 (Figure 2). Although statistical analysis was not performed for the case study groups including the Skin of Color group, Melasma group, and Acne Subgroup, all dermatologist graded photodamage parameters and overall acne severity decreased over the course of the study (Figure 3). Digital photography demonstrated obvious antiaging effects (Figure 4), as well as benefits to acne (Figure 5) and melasma (Figure 6). Self-assessed aging parameters were improved, providing subjective support of the clinical data (Table 3, Figure 7). The PHA/Bionic supportive home care products were well-tolerated when used in conjunction with the retinol peel. The 3% retinol peel, in conjunction with a homecare regimen, was well tolerated in subjects with photodamage, acne, hyperpigmentation/ melasma, and skin of color (Fitzpatrick skin types IV-VI), and demonstrated visible improvements in antiaging parameters, acne, and melasma.
CONCLUSION
Patients seek non-invasive cosmetic treatments for aging concerns,
acne, and hyperpigmentation. The tested high-strength
retinol superficial peel formulation, containing 3% retinol, with
triethyl citrate and acetyl tyrosinamide, significantly improved
overall photodamage after one peel. In addition, after a series
of 4 retinol peels, along with a polyhydroxy acid-based homec-
