Additional tests also found that skin treated with CER cream, compared with skin treated with the reference cream, had superior resilience to tape-stripping damage.31 After tapestripping, TEWL was lower for the CER cream treated skin than the reference treated skin.31 Skin barrier integrity, as measured by the area under the TEWL curve, was also greater for the CER cream- than the reference-treated skin.31
The study also included an irritant challenge where sodium lauryl sulfate patches were applied on day 29, removed on day 30, and reactions measured on day 31. The areas treated with CER cream had a significantly (P<.0001) smaller change in the visual redness score than the areas treated with the reference cream and a significantly (P<.0001) lower change in TEWL. These results suggest that compared with a paraffin-based emollient, CER cream protects better against irritants.30, 32
Results from the Survey
The percentages of each rosacea subtype the panel reported seeing were: mostly-erythematous (40%-65%), mostlypapulopustular (20%-45%), mostly-phymatous (2%-10%), and a combination (0%- 21%). For treatment choices (N=4 panel), doxycycline was the most frequently identified treatment for both papulopustular and combination rosacea, topical metronidazole was the most frequently identified for erythematous rosacea, and laser, surgery, and isotretinoin were the most frequently identified treatments for phymatous rosacea (Figure 4). These treatments are in line with published recommendations.35
The panel was asked to list their first, second, and third choice of non-prescription skincare products for rosacea monotherapy (Table 1), adjunctive therapy (Table 2), and maintenance therapy (Table 3). The panels' first choices are presented in graph format for rosacea monotherapy (Figure 5A), adjunctive therapy (Figure 5B), and maintenance therapy (Figure 5C). For rosacea monotherapy, serum or cream with neurosensine (N=2) was used. For adjunctive therapy, the response was a ceramidecontaining moisturizer (N=2), and for maintenance therapy, the response was moisturizers with ceramides (N=3).
Regarding ingredients in non-prescription moisturizers that the panel (N=4) considered the most important for their patients with rosacea (some panels listed multiple ingredients): ceramides were mentioned 4 times, and other ingredients once each (Figure 5D). When asked which ingredients in nonprescription cleansers they considered the most important for their rosacea patients, the panel (N=4) answered: syndets or cleansing lotions, neurosensine, gentle skin cleansing, and gentle with minimal irritancy. When asked which ingredients in non-prescription cleansers should not be used for their rosacea patients, the panel (N=4) answered: lactic acid, glycolic acid, salicylic acid, retinol formulations that contain astringents and abrasives, irritants, or with peeling effects, traditional soaps, and keratolytics. When asked which ingredients in non-prescription moisturizers should not be used in their rosacea patients, the panel answered: lactic acid, glycolic acid, salicylic acid, retinol, heavy ingredients, a high percentage of alpha hydroxy acid,
