Tumor Necrosis Factor Inhibitor-Induced Psoriasis in a Pediatric Crohn’s Disease Patient Successfully Treated with Ustekinumab

March 2020 | Volume 19 | Issue 3 | Case Reports | 328 | Copyright © March 2020


Published online February 21, 2020

Lauren Bonomo MD,a Ellen H. de Moll MD,b Linden Li,b Lauren Geller MD,b Michael I. Gordon DO,c David Dunkin MDd

aIcahn School of Medicine at Mount Sinai, New York, NY bDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY cNova Southeastern University College of Osteopathic Medicine, Davie, FL dDepartment of Pediatric Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, Nd

3. Rahier, J.F., et al., Severe skin lesions cause patients with inflammatory bowel disease to discontinue anti-tumor necrosis factor therapy. Clin Gastroenterol Hepatol. 2010;8(12):1048-55.
4. Cullen, G., et al., Psoriasis associated with anti-tumour necrosis factor therapy in inflammatory bowel disease: a new series and a review of 120 cases from the literature. Aliment Pharmacol Ther. 2011;34(11-12):1318-27.
5. Shmidt, E., et al., Psoriasis and palmoplantar pustulosis associated with tumor necrosis factor-alpha inhibitors: the Mayo Clinic experience, 1998 to 2010. J Am Acad Dermatol. 2012.67(5): 179-85.
6. Guerra, I., et al. Incidence, clinical characteristics, and management of psoriasis induced by anti-TNF therapy in patients with inflammatory bowel disease: a nationwide cohort study. Inflamm Bowel Dis. 2016;22(4):894-901.
7. Klufas, D.M., J.M. Wald, and B.E. Strober. Treatment of moderate to severe pediatric psoriasis: a retrospective case series. Pediatr Dermatol. 2016;33(2):142-9.
8. Rinawi, F., et al., Ustekinumab for resistant pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2016;62(4):34-5.
9. Bishop, C., et al. Ustekinumab in pediatric Crohn disease patients. J Pediatr Gastroenterol Nutr. 2016;63(3):348-51.
10. Min MS, Shroff A, Rose S, Lebwohl M, Guttman-Yassky E. Ustekinumab as therapy for psoriasis in a 2-year-old girl. J Eur Acad Dermatol Venereol. 2016;30(11):109-110.
11. Bertrand V, El Haite A, Carré D. Efficiency of ustekinumab in Crohn's disease with severe psoriasiform rash induced by biotherapies in an adolescent. Pediatr Dermatol. 2017;34(4): 214-215
12. Matsumoto S, Mashima H. Efficacy of ustekinumab against infliximabinduced psoriasis and arthritis associated with Crohn's disease. Biologics. 2018;19(12):69-73.

AUTHOR CORRESPONDENCE

Michael I. Gordon DO gordonmi99@gmail.com