In these case studies, exosomes rapidly and dramatically accelerated recovery times for a range of patients with no reported adverse effects. For those patients who prioritize or require minimized downtime, exosomes are a valuable complement to treatment. For patients with the potential for scarring, this type of therapy may be invaluable, in particular for post-surgical scarring. That the patient in Figure 3 demonstrated dramatically accelerated wound healing (10 days to complete wound closure vs 6 months predicted) displayed no scarring or fibrosis is a testament to the potential therapeutic application of these vessels that is further backed by in vitro findings and recognition that exosomes can promote healing through various pathways at multiple stages in wound healing.11,13 Taken together these case studies emphasize the need for further clinical study of these potentially significant modifiers of infection, inflammation, and wound healing following both trauma and surgical procedures.
ACKNOWLEDGEMENTS
Medical writing assistance was provided by Ginny Vachon PhD, Principal Medvantage, LLC, Atlanta, Georgia under the direction of the authors. Funding for this support was provided by Exocel Bio.
DISCLOSURES
Dr Peredo is a trainer for Galderma and an Advisory Board Member for Exocel Bio. Dr Shivananjappa is a Scientific Advisor for Exocel Bio.
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AUTHOR CORRESPONDENCE
Marina Peredo MD peredomd@gmail.com
