The Treatment of Inflammatory Facial Dermatoses With Topical Corticosteroids: Focus on Clocortolone Pivalate 0.1% Cream

October 2012 | Volume 11 | Issue 10 | Original Article | 1194 | Copyright © October 2012


Leon H. Kircik MD FAADa and James Q. Del Rosso DO FAOCDb

aIndiana University School of Medicine, Indianapolis, IN Mount Sinai Medical Center, New York, NY; DermResearch, PLLC, Louisville, KY bValley Hospital Medical Center, Las Vegas, NV; Touro University College of Osteopathic Medicine, Henderson, NV Las Vegas Skin & Cancer Clinics, Dermatology and Cutaneous Surgery, Las Vegas and Henderson, NV

matitis and psoriasis proved to be effective and safe over short courses of therapy for disease flares. In the study reported here, clocortolone pivalate 0.1% cream was effective and safe for the treatment of facial seborrheic dermatitis, atopic dermatitis, and psoriasis. The clocortolone pivalate molecule exhibits unique structural characteristics that impact upon efficacy and may also modify AEs in an advantageous manner. The distinctive halogen positioning and pivalate group produce a TC in the upper end of the mid-potency range. In addition, the cream formulation of clocortolone pivalate, contains three emollient ingredients (white petrolatum, mineral oil, stearyl alcohol) and is devoid of fragrance, propylene glycol, and lanolin, all factors that are favorable when treating inflamed or eczematous skin.

DISCLOSURES

Dr. Kircik serves as as advisor, investigator, consultant, and speaker for Bayer, Galderma, Promius, Stiefel, GSK, LeoPharma, Taro, and Valeant. Dr. Del Rosso has served as an advisor or consultant for: Allergan; Bayer Dermatology; Dermira; Galderma; LeoPharma; Medicis; Onset Therapeutics; Pharmaderm; Primus, Promius, Ranbaxy; Taro; TriaBeauty; Unilever; Valeant/Coria Dermatology, Warner Chilcott. Dr. Del Rosso has served as a speaker or a member of a speakers bureau for: Allergan; Bayer Dermatology; Galderma; LeoPharma; Medicis; Onset Therapeutics; Pharmaderm; Promius; Taro; TriaBeauty; Unilever; Valeant/Coria Dermatology, Warner Chilcott. Dr. Del Rosso has received grants for clinical research from: Allergan, Inc.; Amgen; Coria Laboratories, Ltd.; Galderma Laboratories, L.P.; Intendis Inc.; Medicis Pharmaceutical Corporation; Graceway Pharmaceuticals, LLC; Ortho Dermatology; Onset Therapeutics; Stiefel Laboratories Inc.; Triax Pharmaceuticals; Warner Chilcott. Dr. Del Rosso has no relevant stock ownership.

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ADDRESS FOR CORRESPONDENCE

Leon H. Kircik MDPhysicians Skin Care, PLLC1169 Eastern Parkway Suite 2310Louisville, KY 40217wedoderm@yahoo.com
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