The Many Faces of Pediatric Acne: How to Tailor Nonprescription Acne Treatment and Skincare Using Cleansers and Moisturizers

June 2022 | Volume 21 | Issue 6 | 602 | Copyright © June 2022


Published online May 31, 2022

Lawrence A. Schachner MD FAAD FAAPa, Anneke Andriessen PhDb, Latanya Benjamin MD FAAD FAAPc, Madelyn Dones MDd, Leon H. Kircik MD FAADe, Ayleen Pinera-Llano MDf, Linda Keller MDg, Adelaide A. Hebert MD FAADh

aDivision of Pediatric Dermatology, Department of Dermatology and Cutaneous Surgery, Department of Pediatrics, Leonard M. Miller School of Medicine, University of Miami, FL
bRadboud UMC, Nijmegen and Andriessen Consultants, Malden, The Netherlands
cAssociate Professor of Pediatric Dermatology, Department of Women’s and Children’s Health, Florida Atlantic University, Boca Raton, FL
dBaptist Health Hospital, Nicklaus Childrens’ Hospital, Miami, FL
eIchan School of Medicine at Mount Sinai, New York, NY; Indiana University Medical Center, Indianapolis, IN; Physicians Skin Care, PLLC, Louisville, KY; DermResearch, PLLC, Louisville, KY; Skin Sciences, PLLC, Louisville, KY
fKing Bay Pediatrics, Miami, FL; General Pediatrics, Nicklaus Children’s Hospital, Miami, FL
gBaptist Health Baptist Hospital, Baptist Health South Miami Hospital, Miami, FL
hDepartment of Dermatology and Pediatrics, McGovern Medical School, Houston, TX; Children’s Memorial Hermann Hospital, Houston, TX

15. Parikh SA, Davis SA, Krowchuck DP, Feldman SR. Common use of prescription off-label acne therapy in children younger than 12 years old. Ped Derm. 2014;31(5):551-55.
16. Smith Begolka W, et al. American Academy of Dermatology evidencebased guideline development process: responding to new challenges and establishing transparency. J Am Acad Dermatol. 2011;64(6):e105-12. doi: 10.1016/j.jaad.2010.10.029.
17. Bree AF, Siegfried EC. Acne vulgaris in preadolescent children: recommendations for evaluation. Pediatr Dermatol. 2014;31:27-32.
18. Karciauskiene J, Valiukeviciene S, Gollnick H, Stang A. The prevalence and risk factors of adolescent acne among schoolchildren in Lithuania: a crosssectional study. J Eur Acad Dermatol Venereol. 2014;28:733-740.
19. Eun DH, Kim JY, Jang YH, Lee SJ, Lee WJ. Clinical investigation on preadolescent acne. Korean Dermatol Association and Korean Society for Invest Dermatol. 2019;31(2):249-251.
20. Prohic A, Jovovic Sadikovic T, Krupalija-Fazlic M, Kuskunovic-Vlahovljak S. Malassezia species in healthy skin and in dermatological conditions. Int J Dermatol. 2016;55(5):494-504. doi: 10.1111/ijd.13116.
21. Tamayo CS, Janniger CK, Micali G, Schwartz RA. Neonatal and infantile acne vulgaris: an update. Cutis. 2014;94(1):13-16.
22. Piggott CDS, Eichenfield LF, Lucky AW. Acne in children. In: Shalita AR, Del Rosso JQ, Webster GF, eds. Acne Vulgaris. New York, NY: Informa Healthcare; 2011:182–197.
23. Halvorsen JA, Stern RS, Dalgard F, Thoresen M, Bjertness E, Lien L. Suicidal ideation, mental health problems, and social impairment are increased in adolescents with acne: a population-based study. J Invest Dermatol. 2011;131(2):363-70.
24. Sundström A, Alfredsson L, Sjölin-Forsberg G, Gerdén B, Bergman U, Jokinen J. Association of suicide attempts with acne and treatment with isotretinoin: retrospective Swedish cohort study. BMJ. 2010;341:c5812.
25. Dreno B, Pecastaings S, Corvec S, Veraldi S, Khammari A, Roques C. Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates. J Eur Acad Dermatol Venereol. 2018;32Suppl 2:5- 14.
26. Perkins AC, Cheng CE, Hillebrand GG, et al. Comparison of the epidemiology of acne vulgaris among Caucasian, Asian, continental Indian and African American women. J Eur Acad Dermatol Venereol. 2011;25:1054-60.
27. Davis SA, Narahari S, Feldman SR, Huang W, et al. Top dermatologic conditions in patients of color: An Analysis of Nationally Representative Data. J Drugs Dermatol. 2012;11(4):466-73.
28. Abad‐Casintahan F, Chow SK, Goh CL et al. Frequency and characteristics of acne‐related post‐inflammatory hyperpigmentation. J Dermatol. 2016;43(7):826– 828.
29. Tan J, Kang S, Leyden J. Prevalence and risk factors of acne scarring among patients consulting dermatologists in the United States. J Drugs Dermatol. 2017;16(2):97–102.
30. Dréno B, Bissonnete R, Tan J, et al. Prevention and reduction of atrophic acne scars with adapalene 0.3%/benzoyl peroxide 2.5% gel in subjects with moderate or severe facial acne: Results of a 6-month randomized, vehiclecontrolled trial using intra-individual comparison. Am J Clin Dermatol. 2018;19:275-286. https://doi.org/10.1007/s40257-018-0352-y
31. Alexis AF, Harper JC, Stein Gold LF, Tan JKL. Treating acne in patients with skin of color. Semin Cutan Med Surg. 2018;37(supp3):S71-S73.
32. Thiboutot DM, Dreno B, Abanmi A, et al. Practical management of acne for clinicians: an international consensus from the global alliance to improve outcomes in acne. J Am Acad Dermatol. 2018;78(2S1):S1–23.
33. Liu H, Yu H, Liu L, et al. Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid for acne. Cochrane Database Syst Rev. 2020;(5):CD011368.
34. Del Rosso JQ. Clinical relevance of skin barrier changes associated with the use of oral isotretinoin: the importance of barrier repair therapy in patient management. J Drugs Dermatol. 2013;12(6):626-31.
35. Pappas A, et al. Seasonal changes in epidermal ceramides are linked to impaired barrier function in acne patients. Experimental Dermatol. 2018;27(8):833-836.
36. Lynde CW, Andriessen A, Barankin B, et al. Moisturizers and ceramidecontaining moisturizers may offer concomitant therapy with benefits. J Clin Aesthet Dermatol. 2014;7(3):18-26.
37. Araviiskaia E, Dreno B. The role of dermocosmetics in acne vulgaris. J Eur Acad Dermatol Venereol. 2016;30:926-935.
38. Dreno B, Araviiskaia E, Kerob D, Andriessen A, Anifilova M, Fabbrocini G. Nonprescription acne vulgaris treatments: Their role in our treatment armamentarium—An international panel discussion. J Cosmet Dermatol. 2020;19(9):2201-2211. DOI: 10.1111/jocd.13497
39. Andriessen A, Rodas AC, Gonzalez CG, et al. Over the counter products for acne treatment and maintenance in Latin America: A review of current clinical practice. J Drugs Dermatol. 2021;20(4):1-9. doi 10.36849/JDD.2021.5779
40. Baldwin HE, Friedlander SF, Eichenfield LF, et al. The effects of culture, skin color, and other nonclinical issues on acne treatment. Semi Cutan Med Surg. 30:S12-S15:12.
41. Alexis AF, Woolery-Lloyd H, Williams K, et al. Racial/ethnic variations in acne: Implications for treatment and skin care recommendations for acne patients with skin of color. J Drugs Dermatol. 2021;20(7):716-725. doi:10.36849/ JDD.6169

AUTHOR CORRESPONDENCE

Anneke Andriessen PhD anneke.a@tiscali.nl