gives the keywords used for the literature search.
The searches resulted in 11 publications included in the following discussion (Figure 1).
The searches resulted in 11 publications included in the following discussion (Figure 1).
DISCUSSION
Damaging Effects of the Exposome
The term "exposome" was first described in 2005 by the American cancer epidemiologist Christopher Wild. He defined the totality of exposures to which an individual is subjected from conception to death, which influences general or skin health beyond genetics (Box 2).10 Although the exposome concept was introduced over a decade ago, the exposome of human skin has only recently started to receive more attention from the scientific community.11 This is reflected by a cursory search of the term "skin exposome", which in itself resulted in only 35 PubMed articles, with over 74% (26/35) of manuscripts published in the last 4 years (data on file).
A review by Krutmann et al11 defined the exposome based on the existing knowledge regarding interactions between the skin and the environment. As it relates to skin health and aging, the exposome includes internal and external factors. Another review by Passeron et al12 investigated the impact on the skin of specific exposome factors, including solar exposure, air pollution, hormones, nutrition, and psychological factors. These authors concluded that photoaging, the development
The term "exposome" was first described in 2005 by the American cancer epidemiologist Christopher Wild. He defined the totality of exposures to which an individual is subjected from conception to death, which influences general or skin health beyond genetics (Box 2).10 Although the exposome concept was introduced over a decade ago, the exposome of human skin has only recently started to receive more attention from the scientific community.11 This is reflected by a cursory search of the term "skin exposome", which in itself resulted in only 35 PubMed articles, with over 74% (26/35) of manuscripts published in the last 4 years (data on file).
A review by Krutmann et al11 defined the exposome based on the existing knowledge regarding interactions between the skin and the environment. As it relates to skin health and aging, the exposome includes internal and external factors. Another review by Passeron et al12 investigated the impact on the skin of specific exposome factors, including solar exposure, air pollution, hormones, nutrition, and psychological factors. These authors concluded that photoaging, the development
