Seeing the Treatment of Psoriasis in a New Light: A Novel Medical Device Utilizing Localized Coal Tar and Narrowband UVB for Targeted Treatment of Plaque Psoriasis

June 2021 | Volume 20 | Issue 6 | Features | 701 | Copyright © June 2021


Published online May 19, 2021

Nicholas D. Brownstone MD, Alina Bridges DO, Tina Bhutani MD MAS, Evan Anderson MS, Jeffrey Sugarman MD PhD

University of California, San Francisco, Department of Dermatology, Psoriasis and Skin Treatment Center, San Francisco, CA

14, 22, and 30, respectively, suggesting a therapeutic effect sustained beyond the treatment period. Approximately one third of patients remained clear at week 22. At week 30, the treatment arm with coal tar and UVB novel medical device’s TPA score (2.8) was superior to the control’s TPA score (5.1). No significant adverse events were reported, and the most common adverse event was folliculitis.

DISCUSSION

Although Goeckerman therapy has been well studied as an effective therapy for psoriasis, it is not widely used given the travel required, time consuming regimen, and specialized services needed. Here we report a significant reduction in plaque severity as well as a sustained response after a home-based treatment utilizing the two main components of the Goeckerman regimen.

DISCLOSURES

Dr. Jeffrey Sugarman and Evan Anderson own shares of Luma Therapeutics, the company that developed the technology.
Funding: This study was sponsored by Luma Therapeutics Trial registered on clintrials.gov: NCT03180866

ACKNOWLEDGMENTS

Dr. Jeffrey Sugarman, Principal Investigator, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

REFERENCES

1. Elmets CA, Lim HW, Stoff B, et al. Joint American Academy of Dermatology– National Psoriasis Foundation guidelines of care for the management and treatment of psoriasis with phototherapy. J Am Acad Dermatol. 2019;81(3):775-804.doi:10.1016/j.jaad.2019.04.042
2. Foerster J, Dawe R. Phototherapy achieves significant cost savings by the delay of drug-based treatment in psoriasis. Photderm Photoimm Photomed. 2020;36(2):90-96. doi:10.1111/phpp.12511
3. Yu Z, Huang KP, Buzney EA. Creating and Managing a Phototherapy Center. Dermatol Clin. 2020;38(1):137-143.doi:10.1016/j.det.2019.08.014

AUTHOR CORRESPONDENCE

Nicholas D. Brownstone MD Nicholas.Brownstone@ucsf.edu