In the setting of a negative KOH and a lack of response to treatment
measures, Gram staining or a bacterial culture can easily
be performed to exclude bacterial folliculitis. If these measures
fail to confirm a diagnosis, the more rare causes of diaper dermatitis
should be considered. These include allergic contact
dermatitis, psoriasis, Langerhans cell histiocytosis, and acrodermatitis
enteropathica.6 A consideration of family history, a
complete dermatologic examination, a biopsy, and serologic
testing for zinc levels may be considered in this circumstance.
Disclosures
Robert Brodell declares the following potential conflicts of interest:
Speaker's Bureau: Allergan; Galderma; 3M/Graceway
Pharmaceuticals; GlaxoSmithKline/Stiefel; Dermik; Novartis
Pharmaceuticals Corporation; Sanofi-Aventis; Medicis; PharmaDerm,
a division of Nycomed US Inc. Consultant: Galderma
Laboratories, LP; Medicis; Dow Pharmaceuticals Sciences;
Promius. Advisory Boards: Dow Pharmaceuticals Sciences;
Nycomed US Inc. Grant/Research Support; Galderma; Abbott
Laboratories; Dow Pharmaceuticals Sciences. Ms. Tucker, Dr.
Emerson, and Dr. Wyatt have no conflicts.
References
- Ward DB, Fleischer AB, Feldman SR, Krowchuk DP. Characterization of diaper dermatitis in the United States. Arch Pediatr Adolesc Med. 2000; 154:943-946.
- Adam, R. Skin care of the diaper area. Pediatr Dermatol. 2008; 24(4):427-433.
- Scheinfeld N. Diaper dermatitis a review and brief survey of eruptions of the diaper area. Am J Clin Dermatol. 2005; 6(5):273-281.
- Gupta AK, Skinner AR. Management of diaper dermatitis. Int J Dermatol. 2004; 43:830-834.
- Nanda S, Reddy BS, Ramji S, Pandhi D. Analytical study of pustular eruptions in neonates. Pediatri Dermatol. 2002; 19(3):210-215.
- Ravanfar P, Wallace J, Pace N. Diaper dermatitis: a review and update. Curr Opin Pediatr. 2012; 24:1-8.
AUTHOR CORRESPONDENCE
Robert T. Brodell MDrbrodell@umc.edu