by facilitating immune cell trafficking. Recently, a topical body firming moisturizer containing adipose targeting agents was shown to induce lipolysis in vitro and reduce upper arm circumference.7 Another topical body product improved clinical outcomes when combined with cryolipolysis.8 Both of these topical body treatment products employ mechanisms of action that partially overlap with TTC (eg, ECM stimulation, lipolysis), but neither product targets the full spectrum of key biological pathways that TTC addresses. This combinatorial approach is key to achieving optimal outcomes in skin quality, whether used as a standalone body treatment or when combined with body contouring procedures.
DISCLOSURES
KL Smith is a member of the Speaker’s Bureau and Advisory Board for Allergan Aesthetics, an AbbVie Company. P Nido, P Maitra, T Cheng, and K Kadoya are employees of AbbVie, Inc, and may own stock in the company.
This study was funded by Allergan Aesthetics, an AbbVie company, Irvine, CA. Writing assistance and editorial support was provided by Liza Selwan-Lewis, PhD, an employee of AbbVie, Inc. All authors met the ICMJE authorship criteria. Neither honoraria nor compensation was provided for authorship.
Funding: This research was supported by Allergan Aesthetics, an AbbVie Company. Employees of AbbVie participated in the research, interpretation of data, review of the manuscript, and the decision to submit for publication.
This study was funded by Allergan Aesthetics, an AbbVie company, Irvine, CA. Writing assistance and editorial support was provided by Liza Selwan-Lewis, PhD, an employee of AbbVie, Inc. All authors met the ICMJE authorship criteria. Neither honoraria nor compensation was provided for authorship.
Funding: This research was supported by Allergan Aesthetics, an AbbVie Company. Employees of AbbVie participated in the research, interpretation of data, review of the manuscript, and the decision to submit for publication.
ACKNOWLEDGMENT
The authors gratefully acknowledge Carlos Alvarado for
technical support.
REFERENCES
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2. Gopaul, R. Body beauty: insights into non-facial skin aging. in Cosmetics & Toiletries. Vol 136 26-32 (2021).
3. Rittie L, Fisher GJ. Natural and Sun-Induced Aging of Human Skin. Cold Spring Harbor Perspectives in Medicine. 5, a015370-a015370 (2015).
4. Eckhart L, Tschachler E, Gruber F. Autophagic control of skin aging. Frontiers in Cell and Developmental Biology. 7(2019).
5. Kruglikov IL, Scherer PE. Skin aging: are adipocytes the next target? Aging. 8, 1457-1469 (2016).
6. Kov cs D, Fazekas F, Oláh A, TörÅ‘csik D. Adipokines in the skin and in dermatological diseases. International Journal of Molecular Sciences. 21, 9048 (2020).
7. Kavali CM, Nguyen TQ, Zahr AS, Jiang LI, Kononov T. A randomized, doubleblind, split-body, placebo-controlled clinical study to evaluate the efficacy and tolerability of a topical body firming moisturizer for upper arm rejuvenation. Aesthetic Surgery Journal. 41, NP472-NP483 (2020).
8. Widgerow AD, Moradi A, Poehler J. A double-blind randomized controlled trial evaluating the efficacy and tolerability of a topical body treatment in combination with cryolipolysis procedures. J Drugs Dermatol. 18, 342-348 (2019).
2. Gopaul, R. Body beauty: insights into non-facial skin aging. in Cosmetics & Toiletries. Vol 136 26-32 (2021).
3. Rittie L, Fisher GJ. Natural and Sun-Induced Aging of Human Skin. Cold Spring Harbor Perspectives in Medicine. 5, a015370-a015370 (2015).
4. Eckhart L, Tschachler E, Gruber F. Autophagic control of skin aging. Frontiers in Cell and Developmental Biology. 7(2019).
5. Kruglikov IL, Scherer PE. Skin aging: are adipocytes the next target? Aging. 8, 1457-1469 (2016).
6. Kov cs D, Fazekas F, Oláh A, TörÅ‘csik D. Adipokines in the skin and in dermatological diseases. International Journal of Molecular Sciences. 21, 9048 (2020).
7. Kavali CM, Nguyen TQ, Zahr AS, Jiang LI, Kononov T. A randomized, doubleblind, split-body, placebo-controlled clinical study to evaluate the efficacy and tolerability of a topical body firming moisturizer for upper arm rejuvenation. Aesthetic Surgery Journal. 41, NP472-NP483 (2020).
8. Widgerow AD, Moradi A, Poehler J. A double-blind randomized controlled trial evaluating the efficacy and tolerability of a topical body treatment in combination with cryolipolysis procedures. J Drugs Dermatol. 18, 342-348 (2019).
AUTHOR CORRESPONDENCE
Kuniko Kadoya PhD kuniko.kadoya@abbvie.com
