Polypodium Leucotomos – An Overview of Basic Investigative Findings

February 2016 | Volume 15 | Issue 2 | Original Article | 224 | Copyright © February 2016


Brian Berman MD PhD,a,b Charles Ellis MD,c and Craig Elmets MDd,*

aCenter for Clinical and Cosmetic Research, Aventura, FL
bEmeritus Professor of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine,Miami, FL
cUniversity of Michigan Medical School, Ann Arbor, MI
dUniversity of Alabama at Birmingham, Birmingham, AL
*Supported by NIH Grant AR050948

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  2. Mulero M, Rodríguez-Yanes E, Nogués MR, et al. Polypodium leucotomos extract inhibits glutathione oxidation and prevents Langerhans cell depletion induced by UVB/UVA radiation in a hairless rat model. Exp Dermatol. 2008;17:653-8.
  3. Jańczyk A, Garcia-Lopez MA, Fernandez-Peñas P, et al. A Polypodium leucotomos extract inhibits solar-simulated radiation-induced TNF-alpha and iNOS expression, transcriptional activation and apoptosis. Exp Dermatol. 2007;16:823-9.
  4. Alonso-Lebrero JL, Domínguez-Jiménez C, Tejedor R, et al. Photoprotective properties of a hydrophilic extract of the fern Polypodium leucotomos on human skin cells. J Photochem Photobiol B. 2003;70:31-7.
  5. Capote R, Alonso-Lebrero JL, García F, et al. Polypodium leucotomos extract inhibits trans-urocanic acid photoisomerization and photodecomposition. J Photochem Photobiol B. 2006;82:173-9.
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  9. Vasänge M, Rolfsen W, Bohlin L. A sulphonoglycolipid from the fern Polypodium decumanum and its effect on the platelet activating-factor receptor in human neutrophils. J Pharm Pharmacol. 1997;49:562-6.
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  11. Middelkamp-Hup MA, Pathak MA, Parrado C, et al. Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin. J Am Acad Dermatol. 2004;51:910-8.
  12. Koch H, Wittern KP, Bergemann J. In human keratinocytes the common deletion reflects donor variabilities rather than chronologic aging and can be induced by ultraviolet A irradiation. J Invest Dermatol. 2001;117:892-7.
  13. Villa A, Viera MH, Amini S, et al. Decrease of ultraviolet A light-induced “common deletion” in healthy volunteers after oral Polypodium leucotomos extract supplement in a randomized clinical trial. J Am Acad Dermatol.2010;62:511-3.
  14. Caccialanza M, Percivalle S, Piccinno R, et al. Photoprotective activity of oral Polypodium leucotomos extract in 25 patients with idiopathic photodermatoses. Photodermatol Photoimmunol Photomed. 2007;23:46-7.
  15. Nestor M S and Berman B. A Safety and Efficacy Study of Oral Heliocare® (Polypodium leucotomos Extract) in Healthy Adult Subjects. Poster at Practical Dermatol Dermatopath Symposium, Vail, Co Aug. 14, 2014.

AUTHOR CORRESPONDENCE

Brian Berman MD PhD……................................... bbmdphd@gmail.com
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