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Dec 10
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Total Defense + Repair: A Novel Concept in Solar Protection and Skin Rejuvenation

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Dec 10
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New Frontiers in Psoriasis Treatment

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This is the 3rd year that I’ve had the opportunity to write an editorial for Journal of Drugs in Dermatology Special Issue on Psoriasis. This is not an onerous task.…
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Dec 10
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Randomized Pilot Clinical Trial of Tofacitinib Solution for Plaque Psoriasis: Challenges of the Intra-Subject Study Design

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INTRODUCTION Psoriasis is a common, debilitating, immune-mediated disease; plaque psoriasis is the most common form, characterized by thickened, erythemato-squamous plaques.1 First-line treatment of mild to moderate plaque psoriasis involves topical…
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Dec 10
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Emerging Oral Immunomodulators for the Treatment of Psoriasis: A Review of Phase III Clinical Trials for Apremilast and Tofacitinib

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INTRODUCTION Psoriasis is a chronic immune-mediated inflammatory condition that affects approximately 2.6% of the population of the United States.1 Psoriasis affects men and women alike, and although the prevalence is…
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Dec 10
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Reproducible Novel Transcriptional Differences Between Psoriatic Lesional and Non-Lesional Skin Show Increased Inflammation and Metabolism

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INTRODUCTION Psoriasis (PS) is a common but complex chronic inflammatory skin disease. It is characterized by red, scaly plaques, which commonly present on the extensor surfaces of the body. Psoriasis…
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Dec 10
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Essential Truths for the Care and Management of Moderate-to-Severe Psoriasis

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INTRODUCTION Since the 2000’s, an interesting dichotomy has emerged in the management of patients with moderate-to-severe psoriasis. Results from clinical trials of biologics demonstrate that clear or nearly clear skin…
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Dec 10
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Effect of Field Treatment of Actinic Keratosis With Ingenol Mebutate Gel on the Identification of Lesions for Biopsy

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INTRODUCTION Actinic keratoses (AKs) are common epidermal lesions that usually manifest clinically as red, brown, or skin-colored, rough papules or plaques on sun-exposed skin sites.1,2 The presence of multiple AKs…
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Dec 10
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Secukinumab Improves Physical Function in Subjects With Plaque Psoriasis and Psoriatic Arthritis: Results from Two Randomized, Phase 3 Trials

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INTRODUCTION Psoriatic arthritis (PsA) is a seronegative spondyloarthropathy characterized by musculoskeletal signs and symptoms (arthritis, enthesitis, spondylitis) with associated joint pain and tenderness.1 It affects an estimated 0.3% to 1.0%…
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Dec 10
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Desoximetasone 0.25% Spray for the Relief of Scaling in Adults With Plaque Psoriasis

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INTRODUCTION Plaque psoriasis is a chronic, inflammatory disease of the skin characterized by a wide array of symptoms such as scaling, itching, redness, and pain.1-3 A survey of 10,676 adults…
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Dec 10
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Erythema of Rosacea: Validation of Patient’s Self-Assessment Grading Scale

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INTRODUCTION Rosacea is a common and chronic skin disorder affecting an estimated 16 million people in the United States.1 Rosacea primarily affects the central facial area (ie, cheeks, nose, chin,…
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Dec 10
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Biologic and Conventional Systemic Therapies Show Similar Safety and Efficacy in Elderly and Adult Patients With Moderate to Severe Psoriasis

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INTRODUCTION The elderly represent a significant proportion of psoriasis vulgaris patients due to the chronic nature of the disease and its bimodal incidence with a second peak near the seventh…
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Dec 10
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The Presence of an Air Gap Between the Nail Plate and Nail Bed in Onychomycosis Patients: Treatment Implications for Topical Therapy

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INTRODUCTION Onychomycosis is a common fungal infection of the toenails or fingernails, representing around half of all nail diseases, and affecting 10%-20% of adults, particularly the elderly where the prevalence…
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