INTRODUCTION Topical tretinoin (all-trans-retinoic acid), a first-line therapy for acne vulgaris treatment, is recommended as maintenance therapy for acne, primarily due to its ability to reduce comedone formation without inducing…

INTRODUCTION AND CLINICAL OVERVIEWPeriorbital Hyperpigmentation (POH) is also known by the following names: periorbital melanosis, periorbital circles, dark circles, dark eye circle, underye circles, perioccular pigmentation, perioccular melanosis, infraorbital melanosis,…

INTRODUCTION Melasma is an acquired hypermelanosis that typically affects sun-exposed areas on the face and presents as symmetric brownish macules and patches coalescing in a reticular pattern.1 An estimated 6…

CASE REPORTAn eight year-old Hispanic female with a history of pre-B cell acute lymphoblastic leukemia presented to our clinic due to excessive hair on her face and arms for 16…

CASE REPORT A new generation of anticancer pharmaceuticals designed to inhibit specific malignancy-associated enzymes has become available in recent years. Vemurafenib represents one such medication and targets the V600E-substituted B-Raf…

Mayo Clinic Jacksonville opened in 1986 on the intracoastal waterway of Florida just miles from Jacksonville Beach, and was the first Mayo Clinic campus outside of Rochester, MN. Initially staffed…

DISCLOSURES The authors have not disclosed any relevant conflicts of interest.AUTHOR CORRESPONDENCEJason C. Sluzevich MDSluzevich.jason@mayo.edu

CASE A 51-year-old African American female presented with a 4-month history of progressive skin ulcers on the lower extremities, associated with severe and unrelenting paresthetic pain that preceded the skin…

Patient and health activists have raised questions about common chemical additives becoming ubiquitous in our environment, including triclosan and bisphenol A. The use of the biocide triclosan has increased exponentially…

FDA Approves First Combo Therapy for Advanced Melanoma The FDA has approved trametinib (Mekinist, GlaxoSmithKline) in combination with dabrafenib (Tafinlar, GlaxoSmithKline) to treat patients with advanced melanoma that is unresectable…

A Randomized, Double-blinded, Regimen-controlled, Phase II, Multicenter Study to Assess the Efficacy and Safety of Two Different Vismodegib Regimens in Patients With Multiple Basal Cell Carcinomas Sponsored by Hoffmann-La Roche,…

The primary reason patients seek aesthetic treatment from dermatologists or plastic surgeons is to combat the signs of aging.1 Increased interest in this goal has been driven by the development…