Intense Pulsed Light: A Methodical Approach to Understanding Clinical Endpoints

February 2021 | Volume 20 | Issue 2 | Case Reports | 203 | Copyright © February 2021


Published online January 10, 2021

Michael B. Lipp DO, Kunal Angra MD, Douglas C. Wu MD PhD, Mitchel P. Goldman MD

Cosmetic Laser Dermatology: A West Dermatology Company, San Diego, CA

higher fluence levels and fewer pulse counts. However, when the IPL is pushed to aggressive parameters, there is a risk of hypopigmentation and hair loss as seen in this case study. Skin type is another important consideration. The patient was a Fitzpatrick skin type III, which is more forgiving, and the outcomes may be an unacceptable outcome if treated on darker skin types. Treatment response and adverse effect profiles will vary greatly with skin type. We recommend that providers titrate their settings based on Fitzpatrick skin type and proceed cautiously in patients with skin types IV–V or history of recent tanning. Additionally, all IPL devices operate differently, and one IPL device may not have the same features (eg, MSP) as another.

The IPL is a highly versatile energy device that can produce excellent clinical outcomes by targeting multiple different chromophores (melanin, oxyhemoglobin/deoxyhemoglobin, and water), improving pigmentation, redness, tone and texture. In addition, treatments are safe and well-tolerated. The goal of this study is to help practitioners better conceptualize and fine tune IPL device settings in order to produce the most effective and safest clinical outcome.

DISCLOSURES

Dr. Goldman conducts clinical studies and received the Stellar M22 on loan from Lumenis Ltd.

REFERENCES

  1. Goldman MP, Eckhouse S. Photothermal sclerosis of leg veins. Dermatol Surg. 1996; (22):323-330.
  2. Raulin C, C Schroeter, E Maushagen-Schnaas. Treatment possibilities with a high-energy pulsed light source (PhotoDerm VL)]. Hautarzt. 1997. 48(12):886- 93.
  3. Raulin C, et al. Treatment of adult port-wine stains using intense pulsed light therapy (PhotoDerm VL): brief initial clinical report. Dermatol Surg. 1997. 23(7):594-7.
  4. Jay H, C Borek. Treatment of a venous-lake angioma with intense pulsed light. Lancet. 1998. 351(9096):112.
  5. Weiss RA, et al., Hair removal with a non-coherent filtered flashlamp intense pulsed light source. Lasers Surg Med. 1999. 24(2):128-32.
  6. Weiss RA, MP Goldman, MA Weiss, Treatment of poikiloderma of Civatte with an intense pulsed light source. Dermatol Surg. 2000. 26(9):823-7; discussion 828.
  7. Wang CC, et al., Intense pulsed light for the treatment of refractory melasma in Asian persons. Dermatol Surg. 2004. 30(9):1196-200.
  8. Kawada A, et al. Clinical improvement of solar lentigines and ephelides with an intense pulsed light source. Dermatol Surg. 2002. 28(6):504-8.
  9. Wu DC, et al. Comparison of intense pulsed light with 1,927-nm fractionated thulium fiber laser for the rejuvenation of the chest. Dermatol Surg. 2014. 40(2):129-33.
  10. Wat H, et al. Application of intense pulsed light in the treatment of dermatologic disease: a systematic review. Dermatol Surg. 2014. 40(4):359- 77.
  11. Alam M, et al. Nonablative laser and light treatments: histology and tissue effects--a review. Lasers Surg Med. 2003. 33(1):30-9.
  12. Cho EB, et al. Effect of intense pulsed light on rat skin. Dermatol Surg. 2012. 38(3):430-6.
  13. Goldberg DJ. New collagen formation after dermal remodeling with an intense pulsed light source. J Cutan Laser Ther. 2000. 2(2):59-61.
  14. Negishi K, et al. Full-face photorejuvenation of photodamaged skin by intense pulsed light with integrated contact cooling: initial experiences in Asian patients. Lasers Surg Med. 2002. 30(4): 298-305.
  15. Goldberg DJ, KB Cutler. Nonablative treatment of rhytids with intense pulsed light. Lasers Surg Med. 2000. 26(2):196-200.
  16. Bitter PH. Noninvasive rejuvenation of photodamaged skin using serial, fullface intense pulsed light treatments. Dermatol Surg. 2000. 26(9):835-42; discussion 843.
  17. Goldman MP, RA Weiss, MA Weiss, Intense pulsed light as a nonablative approach to photoaging. Dermatol Surg. 2005. 31(9 Pt 2):179-87; discussion 1187.
  18. Raulin C, B Greve, S. Hammes. Cold air in laser therapy: first experiences with a new cooling system. Lasers Surg Med. 2000. 27(5):404-10.
  19. Meesters AA, et al. Transcutaneous laser treatment of leg veins. Lasers Med Sci. 2014. 29(2):481-92.
  20. Goldman MP. One laser for a cosmetic/dermatologic practice. J Clin Aesthet Dermatol. 2011. 4(5):18-21.

AUTHOR CORRESPONDENCE

Michael B. Lipp m.b.lipp@gmail.com