INTRODUCTION
Many patients avoid retinoic acid due to skin irritation after application, thus reducing perceived efficacy. Retinol is a less irritating topical that carries many of the same benefits as retinoic acid with less irritation and is available without a prescription. Additional ingredients, such as niacinamide and terminalia chebula have demonstrated antiaging benefits as well.7,8 Using a liposomal delivery system, a novel formulation was produced to provide an effective and tolerable facial treatment of rhytids, redness, discoloration, and texture. A 12-week facial study was conducted to evaluate the efficacy of a novel topical on the reduction of fine lines, erythema, dyspigmentation, as well as the improvement in skin texture. A self-perception questionnaire was also completed by all participants at the endpoint of the study.
CASE
In order to evaluate the efficacy of the PCA SKIN® Intensive Age Refining Treatment: 0.5% pure retinol night, a group of Fitzpatrick Type II women between the ages of 36 and 61 were recruited with an N=16 (subjects enrolled) and N= 13 (subjects completed and analyzed) for the study. Three withdrew due to issues unrelated to the study.
Following completion of an IRB approved informed consent (US Investigational Review Board, Miami, FL) and meeting all inclusion criteria and none of the exclusion criteria, baseline images were captured before the start of the study at week 0 as well as every two weeks until the study endpoint at week 12. For all participants, images and filter data were captured of the left, right, and front of the face using the Canfield Visia® imaging technology (model Generation 7, software version 7). Filter images specifically analyzed were those tracking changes in brown spots, red areas, wrinkles, and skin texture. Visia® images of all participants were evaluated by the dermatologist investigator.
Following completion of an IRB approved informed consent (US Investigational Review Board, Miami, FL) and meeting all inclusion criteria and none of the exclusion criteria, baseline images were captured before the start of the study at week 0 as well as every two weeks until the study endpoint at week 12. For all participants, images and filter data were captured of the left, right, and front of the face using the Canfield Visia® imaging technology (model Generation 7, software version 7). Filter images specifically analyzed were those tracking changes in brown spots, red areas, wrinkles, and skin texture. Visia® images of all participants were evaluated by the dermatologist investigator.
