Effectiveness and Safety of Sculptra Poly-L-Lactic Acid Injectable Implant in the Correction of Cheek Wrinkles
January 2024 | Volume 23 | Issue 1 | 1297 | Copyright © January 2024
Published online December 15, 2023
Sabrina Fabi MD FAAD FAACSa, Tiffani Hamilton MDb, Brenda LaTowsky MDc, Rebecca Kazin MDd, Keith Marcus MDe,f, Flor Mayoral MDg, John Joseph MDh, Deirdre Hooper MDi, Sachin Shridharani MDj,k, Jessica Hicks PhDl, Daniel Brasater PhDm, Felipe Weinberg MDm, Inna Prygova MDm
aCosmetic Laser Dermatology, San Diego, CA
bHamilton Research, LLC, Alpharetta, GA
cInvestigate MD, Scottsdale, AZ
dRKMD, Rockville, MD
eMarcus Medical Spa, Redondo Beach, CA
fMarcus Facial Plastic Surgery, Redondo Beach, CA
gMayoral Dermatology, Coral Gables, FL
hClinical Testing of Beverly Hills, Encino, CA
iAudubon Dermatology/DelRicht Research, New Orleans, LA
jLUXURGERY, New York, NY
kWashington University - St. Louis School of Medicine, Division of Plastic and Reconstructive Surgery, St. Louis, MO
lGalderma Laboratories, L.P. Dallas, TX
mGalderma, Uppsala, Sweden
DISCUSSION
This study demonstrated that PLLA-SCA injections, given as up to 4 individual treatments (approximately 1 month apart), are effective and well tolerated in correcting the appearance of moderate and severe cheek wrinkles. Improvements in wrinkle severity were durable, with significant reductions in severity observed from month 7 (P=0.0043) that were sustained over the 12-month study period (P<0.0001) alongside enhancements in key indicators of skin quality. These outcomes are aligned with previous studies examining wrinkle correction with PLLA-SCA injections and reflect published data regarding the safety and effectiveness of the adapted protocol for immediate administration of reconstituted PLLA-SCA (approved by the US FDA) and support its use moving forward.6,16,17
