Differentiation of NASHA and OBT Hyaluronic Acid Gels According to Strength, Flexibility, and Associated Clinical Significance

January 2024 | Volume 23 | Issue 1 | 1332 | Copyright © January 2024


Published online December 12, 2023

Ake Ohrlund MSc, Per Winlof BSc, Torun Bromee PhD, Inna Prygova MD

Galderma, Uppsala, Sweden

ACKNOWLEDGMENT

Medical writing services were provided on behalf of the authors by Rebecca Down at Copperfox Communications Limited. Support for this assistance was funded by Galderma, Uppsala, Sweden.

REFERENCES

  1. American Society for Dermatologic Surgery. Report of 2019 Procedures, 2020. https://www.asds.net/portals/0/PDF/procedures-survey-results-presentation-2019.pdf. Accessed March 24, 2023. 
  2. Wongprasert P, Dreiss CA, Murray G. Evaluating hyaluronic acid dermal fillers: a critique of current characterization methods. Dermatol Ther. 2022;35(6):e15453. doi:10.1111/dth.15453 
  3. Lee W, Hwang SG, Oh W, et al. Practical guidelines for hyaluronic acid soft-tissue filler use in facial rejuvenation. Dermatol Surg. 2020;46(1):41-49. doi:10.1097/DSS.0000000000001858 
  4. Akinbiyi T, Othman S, Familusi O, et al. Better results in facial rejuvenation with fillers. Plast Reconstr Surg Glob Open. 2020;8(10):e2763. doi:10.1097/ GOX.0000000000002763 
  5. Cassuto D, Bellia G, Schiraldi C. An overview of soft tissue fillers for cosmetic dermatology: from filling to regenerative medicine. Clin Cosmet Investig Dermatol. 2021;14:1857-1866. doi:10.2147/CCID.S276676 
  6. Fagien S, Bertucci V, von Grote E, et al. Rheologic and physicochemical properties used to differentiate injectable hyaluronic acid filler products. Plast Reconstr Surg. 2019;143(4):707e-720e. doi:10.1097/ PRS.0000000000005429 
  7. Michaud T. Rheology of hyaluronic acid and dynamic facial rejuvenation: topographical specificities. J Cosmet Dermatol. 2018;17(5):736-743. doi:10.1111/jocd.12774 
  8. Chacon AH. Fillers in dermatology: from past to present. Cutis. 2015;96(5):E17-9. 
  9. Mansouri Y, Goldenberg G. Update on hyaluronic acid fillers for facial rejuvenation. Cutis. 2015;96(2):85-88. 
  10. Pierre S, Liew S, Bernardin A. Basics of dermal filler rheology. Dermatol Surg. 2015;41 Suppl 1:S120-6. doi:10.1097/DSS.0000000000000334 
  11. Ohrlund A. Evaluation of rheometry amplitude sweep cross-over point as an index of flexibility for HA fillers. J Cosmet Dermatol Sci Appl. 2018;08(02):47- 54. doi:10.4236/jcdsa.2018.82008 
  12. Ohrlund A. Balance of firmness and flexibility for HA fillers. IMCAS Congress, Paris, France. Published online 2020. 
  13. Galderma Laboratories LP, FWTUS. Restylane® Lyft with Lidocaine Product and Safety Information. https://www.galderma.com/us/sites/default/ files/2022-04/Restylane_Lyft_IFU.pdf. Accessed July 21, 2022. 
  14. Edsman K, Nord LI, Ohrlund A, Lärkner H, Kenne AH. Gel properties of hyaluronic acid dermal fillers. Dermatol Surg. 2012;38(7 Pt 2):1170-1179. doi:10.1111/j.1524-4725.2012.02472.x 
  15. Verpaele A, Strand A. Restylane SubQ, a non-animal stabilized hyaluronic acid gel for soft tissue augmentation of the mid and lower face. Aesthet Surg J. 2006;26(1S):S10-17. doi:10.1016/j.asj.2005.09.009 
  16. Galderma Laboratories LP, FWTUS. Restylane-L®. Product and Safety Information. https://www.galderma.com/us/sites/default/files/2018-11/ Restylane-L_IFU.pdf. Accessed July 21, 2022. 
  17. Galderma Laboratories LP, FWTUS. Restylane® Silk. Instructions for Use. https://www.galderma.com/us/sites/g/files/jcdfhc341/files/2018-11/ Restylane_Silk_IFU.pdf. Accessed July 21, 2022. 
  18. Di Gregorio C, Gauglitz G, Partridge J. Individualized treatment algorithm using hyaluronic acid fillers for lifting, contouring, and volumizing the midface. Clin Cosmet Investig Dermatol. 2022;Volume 15:681-690. doi:10.2147/CCID. S353878 
  19. Galderma Canada Inc. Restylane® VolymeTM Instructions for Use. https:// www.restylane.com/ca/sites/default/files/2018-03/Restylane%20 Volyme_90-85520-02.pdf. Accessed July 21, 2022. 
  20. Galderma Laboratories LP, FWTUS. Restylane® Defyne Product and Safety Information. https://www.galderma.com/us/sites/g/files/jcdfhc341/ files/2021-04/90-69324-04%20e-IFU%20Restylane%20Defyne%20USA. pdf. Accessed July 21, 2022. 
  21. Galderma Laboratories LP, FWTUS. Restylane® Kysse Product and Safety Information. https://www.galderma.com/us/sites/g/files/jcdfhc341/ files/2020-04/Restylane_Kysse-IFU.pdf. Accessed July 21, 2022. 
  22. Galderma Laboratories LP, FWTUS. Restylane® Refyne Product and Safety Information. https://www.galderma.com/us/sites/g/files/jcdfhc341/ files/2020-11/90-18814-02%20Refyne%20eIFU.pdf. Accessed July 21, 2022. 
  23. Edsman KLM, Ohrlund A. Cohesion of hyaluronic acid fillers: correlation between cohesion and other physicochemical properties. Dermatol Surg. 2018;44(4):557-562. doi:10.1097/DSS.0000000000001370 
  24. Marcus K, Moradi A, Kaufman-Janette J, et al. A randomized trial to assess effectiveness and safety of a hyaluronic acid filler for chin augmentation and correction of chin retrusion. Plast Reconstr Surg. 2022;150(6):1240e-1248e. doi:10.1097/PRS.0000000000009733. 
  25. Galderma Laboratories LP, FWTUS. Restylane® Contour with Lidocaine Product and Safety Information. https://www.accessdata.fda.gov/cdrh_docs/ pdf14/P140029S032C.pdf. Accessed July 21, 2022. 
  26. Solish N, Bertucci V, Percec I, et al. Dynamics of hyaluronic acid fillers formulated to maintain natural facial expression. J Cosmet Dermatol. 2019;18(3):738-746. doi:10.1111/jocd.12961 
  27. Percec I, Bertucci V, Solish N, et al. An objective, quantitative, dynamic assessment of hyaluronic acid fillers that adapt to facial movement. Plast Reconstr Surg. 2020;145(2):295e-305e. doi:10.1097/ PRS.0000000000006461 
  28. Mezger TG. The Rheoloogy Handbook. EBook European Coatings Symposium Tech Files. 4th ed. Vincentz Network; 2014. 
  29. Lorenc ZP, Ohrlund A, Edsman K. Factors affecting the rheological measurement of hyaluronic acid gel fillers. J Drugs Dermatol. 2017;16(9):876- 882. 
  30. Dayan S, Fabi S, Nogueira A. Lay rater evaluation of naturalness and first impression following treatment of lower face wrinkles with hyaluronic acid fillers. J Cosmet Dermatol. 2021;20(4):1091-1097. doi:10.1111/jocd.13927 
  31. Philipp-Dormston WG, Wong C, Schuster B, et al. Evaluating perceived naturalness of facial expression after fillers to the nasolabial folds and lower face with standardized video and photography. Dermatol Surg. 2018;44(6):826-832. doi:10.1097/DSS.0000000000001419 
  32. La Gatta A, Aschettino M, Stellavato A, et al. Hyaluronan hydrogels for injection in superficial dermal layers: an in vitro characterization to compare performance and unravel the scientific basis of their indication. Int J Mol Sci. 2021;22(11). doi:10.3390/ijms22116005 
  33. Micheels P, Eng MO. Rheological properties of several hyaluronic acid-based gels: a comparative study. J Drugs Dermatol. 2018;17(9):948-954. 
  34. Jones DH, Hessler J, Chapas A, et al. Microcannula injection of large gel particle hyaluronic acid for cheek augmentation and the correction of age-related midface contour deficiencies. Dermatol Surg. 2020;46(4):465-472. doi:10.1097/DSS.0000000000002105 
  35. Wang X, Li B, Li Q. Restylane Lyft for aesthetic shaping of the nasal dorsum and radix: a randomized, no-treatment control, multicenter study. Plast Reconstr Surg. 2022;150(6):1225-1235. doi:10.1097/PRS.0000000000009732 
  36. Huang SH, Tsai TF. Safety and effectiveness of hyaluronic acid fillers with lidocaine for full-face treatment in Asian patients. J Drugs Dermatol. 2020;19(9):836-842. doi:10.36849/JDD.2020.10.36849/JDD.2020.5374 
  37. Philipp-Dormston WG, Schuster B, Podda M. Perceived naturalness of facial expression after hyaluronic acid filler injection in nasolabial folds and lower face. J Cosmet Dermatol. 2020;19(7):1600-1606. doi:10.1111/jocd.13205 
  38. Nikolis A, Bertucci V, Solish N, et al. An objective, quantitative assessment of flexible hyaluronic acid fillers in lip and perioral enhancement. Dermatol Surg. 2021;47(5):e168-e173. doi:10.1097/DSS.0000000000002917 
  39. Bertucci V, Nikolis A, Solish N, et al. Subject and partner satisfaction with lip and perioral enhancement using flexible hyaluronic acid fillers. J Cosmet Dermatol. 2021;20(5):1499-1504. doi:10.1111/jocd.13956 
  40. Bertucci V, Nikolis A, Solish N, et al. Efficacy and safety of flexible hyaluronic acid fillers in lip and perioral enhancement. J Drugs Dermatol. 2021;20(4):402- 408. doi:10.36849/JDD.2021.5525

AUTHOR CORRESPONDENCE

Åke Öhrlund  ake.ohrlund@galderma.com