mean number of AR CAG repeat chain lengths is reported to be shortest for men of African descent (≤18--20), followed by Caucasian men (21--22), and with the longest AR CAG repeat chain lengths noted in East Asian men (22-23).6 As noted above, shorter AR CAG repeat chain lengths correlate directly with increased AR transcriptional activity in both normal skin and in association with disease states.6,7,13,14 Table 3 reviews important observations related to genetic and ethnic variations in androgen receptors and androgen physiology.
Modulation of Androgen Physiology and Therapeutic Interventions in Acne Vulgaris
Despite the central importance of androgens and sebaceous gland activity in the pathophysiology of AV, the availability of therapeutic agents that modulate androgen physiology and AR activity has been relatively limited.4,8,20,21 In the United States (US), the two major approaches have been systemic (oral) therapy with spironolactone (not Food and Drug Administration [FDA]-approved for AV), combination oral contraceptives
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Modulation of Androgen Physiology and Therapeutic Interventions in Acne Vulgaris
Despite the central importance of androgens and sebaceous gland activity in the pathophysiology of AV, the availability of therapeutic agents that modulate androgen physiology and AR activity has been relatively limited.4,8,20,21 In the United States (US), the two major approaches have been systemic (oral) therapy with spironolactone (not Food and Drug Administration [FDA]-approved for AV), combination oral contraceptives
