Third, when certain probiotic strains are placed in contact with
epithelial cells, they are capable of inhibiting inflammatory
pathways and thus the production of inflammatory cytokines.14
As chronic inflammation plays a major role in acne, a natural
immunomodulator could play a needed role.
CONCLUSION
Antibiotics have played a leading role in the treatment of
acne for decades. However, recent issues surrounding resistance
force us to question how much longer we can
count on these drugs, and whether or not they will maintain
their front-line role as safe, effective treatments. It is
our responsibility to take whatever measures we can to limit
the development of further antibiotic resistance, and those
measures are reviewed here. While we fight to maintain the
clinical value of antibiotics, we must also continue to search
for novel approaches to the treatment of acne. An ongoing
search for unique treatments that can be used in concert with
or as alternatives to antibiotics will allow us to best prepare
ourselves for what the future has in store.
DISCLOSURES
Whitney P. Bowe MD has served as a consultant for Johnson &
Johnson Consumer Companies Inc, on an advisory panel for
Galderma Labs, and as a consultant for Procter and Gamble.
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AUTHOR CORRESPONDENCE
Whitney P. Bowe MDwpbowe@gmail.com