endpoint. The subjects also reported that their satisfaction with their periorbital appearance improved by 47% as compared to before treatment.
DISCLOSURES
Dr. Cohen has served as a consultant and clinical trial participant
for Biopelle. Dr. Downie is a consultant for Emepelle and a
researcher.
REFERENCES
1. Archer DF. Postmenopausal skin and estrogen. Gynecol Endocrinol. 2012; 28(supple 3):2-6.
2. Ashcroft GS, Dodsworth J, vanBoxtel E, et al. Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels. Nat Med. 1997;3:1209-1215.
3. Berson D, Cohen JL, Day D, Downie J, Schlessinger J. Emepelle for estrogen deficient skin: Breakthrough for an unmet need. Mod Aesthetics. 2020. Accessed 4 March 2021. Available at:https://modernaesthetics.com/ articles/2020-may-june-insert4/Emepelle for EstrogenDeficientSkin:Breakth roughForAnUnmetNeed
4. Cohen JL. Evaluation of efficacy of a skin care regimen containing methyl estrodiolpropanoate (MEP) for treating estrogen deficient skin. J Drugs Dermatol. 2019;18:1226-1230.
5. Hall G, Phillips TJ. Estrogen and skin: the effects of estrogen, menopause and hormone replacement therapy on the skin. J Am Acad Dermatol. 2005;53:555-568.
6. Mukherjee S, Date A, Patravale V, et al. Retinoids in the treatment of skin aging: An overview of clinical efficacy. Clin Interv Aging. 2006;1:327-348
7. Owen CM, Pal L, Mumford SL, et al. Effects of hormones on skin wrinkles and rigidity vary by race/ethnicity: four-year follow-up from the ancillary skin study of the Kronos Early Estrogen Prevention Study. Fertil Steril. 2016;106:1170-1175
8. Svoboda RM, Del Rosso JQ, Zeichner JA, Draelos ZD. Revisiting the beneficial effects of estrogen on the skin: a comprehensive review of the literature and a look to the future. Skin. 2018;2:308-16
9. Lephart ED, Naftolin F. Menopause and the skin: old favorites and new innovations in cosmeceuticals for estrogen-deficient skin. Dermatol Ther. 2020;https://doi.org/10.1007/s13555-020-00468-7.
10. Rzepecki AK, Murase JE, Juran R, et al. Estrogen-deficient skin: the role of topical therapy. Int J Womens Dermatol. 2019;5:85-90
2. Ashcroft GS, Dodsworth J, vanBoxtel E, et al. Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels. Nat Med. 1997;3:1209-1215.
3. Berson D, Cohen JL, Day D, Downie J, Schlessinger J. Emepelle for estrogen deficient skin: Breakthrough for an unmet need. Mod Aesthetics. 2020. Accessed 4 March 2021. Available at:https://modernaesthetics.com/ articles/2020-may-june-insert4/Emepelle for EstrogenDeficientSkin:Breakth roughForAnUnmetNeed
4. Cohen JL. Evaluation of efficacy of a skin care regimen containing methyl estrodiolpropanoate (MEP) for treating estrogen deficient skin. J Drugs Dermatol. 2019;18:1226-1230.
5. Hall G, Phillips TJ. Estrogen and skin: the effects of estrogen, menopause and hormone replacement therapy on the skin. J Am Acad Dermatol. 2005;53:555-568.
6. Mukherjee S, Date A, Patravale V, et al. Retinoids in the treatment of skin aging: An overview of clinical efficacy. Clin Interv Aging. 2006;1:327-348
7. Owen CM, Pal L, Mumford SL, et al. Effects of hormones on skin wrinkles and rigidity vary by race/ethnicity: four-year follow-up from the ancillary skin study of the Kronos Early Estrogen Prevention Study. Fertil Steril. 2016;106:1170-1175
8. Svoboda RM, Del Rosso JQ, Zeichner JA, Draelos ZD. Revisiting the beneficial effects of estrogen on the skin: a comprehensive review of the literature and a look to the future. Skin. 2018;2:308-16
9. Lephart ED, Naftolin F. Menopause and the skin: old favorites and new innovations in cosmeceuticals for estrogen-deficient skin. Dermatol Ther. 2020;https://doi.org/10.1007/s13555-020-00468-7.
10. Rzepecki AK, Murase JE, Juran R, et al. Estrogen-deficient skin: the role of topical therapy. Int J Womens Dermatol. 2019;5:85-90
AUTHOR CORRESPONDENCE
Joel L. Cohen MD jcohenderm@yahoo.com
