An Open Label Clinical Trial of a Multi-Ingredient Anti-Aging Moisturizer Designed to Improve the Appearance of Facial Skin

A statistically significant percentage of subjects responded favorably to all product efficacy inquiries included in the self-assessment questionnaire. After 12 weeks of twice daily use:

81% of subjects thought that their skin texture looked improved.

75% of subjects thought that their face looked more radiant or brighter.

73% of subjects thought that the fine lines on their face were less noticeable.

78% of subjects thought that their skin looked and felt healthier.

75% of subjects thought that their skin looked younger and firmer.

78% of subjects thought that their skin felt more moisturized.

78% of subjects thought that overall, their skin appearance improved.

A statistically significant percentage of subjects responded favorably to all product aesthetic inquiries included in the self-assessment questionnaire. After 12 weeks of twice daily use:

83% of subjects thought that the product moisturized their skin.

86% of subjects thought that the product scent was pleasant.

86% of subjects thought that the product texture was pleasant.

94% of subjects thought that the product did not leave an unpleasant after-feel.

86% of subjects thought that applying the product was a pleasant experience.

94% of subjects thought that overall, the product did not irritate their skin.

Safety/Tolerability: The multi-ingredient anti-aging moisturizer was well tolerated by the panelists with no statistically significant increase in scores for tolerability parameters at all time points when compared to baseline scores.

The signs of aging of the facial skin such as fine lines, wrinkles, diminished clarity/brightness, increase in visual and tactile roughness, reduction of evenness of skin tone (increase in redness) and reduction in evenness of skin tone (increase in hyperpigmentation) are a complex issue with multiple causes. These causes are related to exposure to ultra-violet radiation, uneven synthesis and distribution of melanin, a deterioration of the dermal-epidermal junction (DEJ), free-radical damage including the degradation of collagen and elastin in the skin as well as the compromised synthesis of new collagen and elastin proteins.

The multi-ingredient anti-aging moisturizer contains various ingredients thought to address these varying causes:

Astragalus Membranaceus Root Extract – contains antioxidants and cycloartane-type saponins, helps overall well-being of the skin

Peptide Blend including Palmitoyl Tripeptide-38 – helps increase collagens I and III as well as the production of DEJ proteins

Standardized Rosemary Leaf Extract (ursolic acid) – a proven, potent antioxidant with moisture barrier protection properties, protective effect in the presence of UVA radiation

THD Ascorbate – Vitamin C derivative, antioxidant with skin brightening and multiple anti-aging properties

Ubiquinone (Coenzyme Q10) – antioxidant, reduces free radical formation

It is hypothesized that a combination of effective ingredients such as those listed above formulated into a moisturizing oil-in-water emulsion base will result in an improvement in the signs of aging around the facial skin. The concerned study appears to positively support the hypothesis as is seen by the results illustrated in Figures 3-9.