2016 Arte Poster Competition First Place Winner: Circadian Rhythm and UV-Induced Skin Damage: An In Vivo Study

September 2016 | Volume 15 | Issue 9 | Features | 1124 | Copyright © September 2016


Linna Guan BS,a,* Amanda Suggs MD,a,* Sayeeda Ahsanuddin BS,a Madeline Tarrillion DO,a Jacqueline Selph MD,a Minh Lam PhD,a and Elma Baron MDa,b,c

aDepartment of Dermatology, Case Skin Diseases Research Center, bCase Western Reserve University/University Hospitals Case Medical Center, cLouis-Stokes VA Medical Center, Cleveland, OH *These authors contributed equally to the work.

AUTHOR CONTRIBUTIONS

All those who met authorship criteria were listed as authors. Authors listed contributed significantly to the manuscript.
E.B. and A.S. conceived and designed the experiments. A.S and J.S. conducted the clinical aspects of the study. L.G. performed the basic science experiments and wrote the manuscript. L.G., M.L., and A.S. analyzed the data. M.L contributed to reagents/ materials/analysis tools. M.T. and S.A. aided in editing of the manuscript and compilation of the data.

DISCLOSURES

This is an investigator-initiated study where the sponsor had no role in the design of the study.

REFERENCES

  1. Bell-Pedersen, D., Cassone, V.M., Earnest, D.J., Golden, S.S., Hardin, P.E., Thomas, T.L., Zoranm, M.J. Circadian rhythms from multiple oscillators: lessons from diverse organisms. Nat Rev Genet 2005; 6(7), 544-556.
  2. Hastings, M., O’Neill, J.S., Maywood, E.S. Circadian clocks: regulators of endocrine and metabolic rhythms. J Endocrinol 2007; 195(2), 187-98.
  3. Refinetti, R., Menaker, M. The circadian rhythm of body temperature. Physiol Behav 1992; 51(3), 613–637.
  4. Purves, D., Augustine, G., Fitzpatrick, D., Katz, L.C., LaMantia, A.S., Mc- Namara, J.O., Williams, M. Circadian Cycle of Sleep and Wakefulness. In Neuroscience, 2nd ed; Purves, D.; Augustine, G.; Fitzpatrick, D.; Katz, L.C.; LaMantia, A.S.; McNamara, J.O.; Williams, M. Eds.; Sinauer Associates: Sunderland, MA, 2001.
  5. Zanello, S.B., Jackson, D.M., Holick, M.F. Expression of the Circadian Clock Genes Clock and Period in Human Skin. J Invest Dermatol 2000; 115(4), 757-760.
  6. Geyfman, M., Andersen, B. Clock genes, hair growth and aging. Aging 2010; 2(3), 122-128.
  7. Matsunaga, N., Itcho, K., Hamamura, K., Ikeda, E., Ikeyama, H., Furuichi, Y., Watanabe, M., Koyanagi, S., Ohdo, S. 24-hour rhythm of aquaporin-3 function in the epidermis is regulated by molecular clocks. J Invest Dermatol 2014; 134(6), 1636-44. doi: 10.1038/jid.2014.13.
  8. Peggy, J., Toufighi, K., Solanas, G., Luis, N.M., Minkwitz, S., Serrano, L., Lehner, B., Benitah, S.A. Human Epidermal Stem Cell Function Is Regulated by Circadian Oscillations. Cell Stem Cell 2013; 13(6), 745-53. doi: 10.1016/j. stem.2013.09.004.
  9. Yosipovitch, G., Xiong, G.l., Haus, E., Sackett-Lundeen, L., Ashkenazi, I., Maibach, H.I. Time-Dependent Variations of the Skin Barrier Function in Humans: Transepidermal Water Loss, Stratum Corneum Hydration, Skin Surface pH, and Skin Temperature. J Invest Dermatol 1998; 110(1), 20-3.
  10. Gaddameedhi, S., Selby, C.P., Kemp, M.G., Ye, R., Sancar, A. The Circadian Clock Controls Sunburn Apoptosis and Erythema of Mouse Skin. J Invest Dermatol 2015; 135(4), 1119-27.
  11. Wlaschek, M., Tantcheva-Poór, I., Naderi, L., Ma, W., Schneider, L.A., Razi- Wolf, Z., Schüller, J., Scharffetter-Kochanek, K. Solar UV irradiation and dermal photoaging. J Photochem Photobiol B 2001; 63(1-3), 41-51.
  12. Ziegler, A., Jonason, A.S., Leffell, D.J.; et al. Sunburn and p53 in the onset of skin cancer. Nature 1994; 372(6508), 773–6.
  13. Harrison, G.I., Young, A.R. Ultraviolet radiation-induced erythema in human skin. Methods 2002; 28(1), 14-9.
  14. Woollons, A., Kipp, C., Young, A.R., Petit-Frère, C., Arlett, C.F., Green, M.H., Clingen, P.H. The 0.8% ultraviolet B content of an ultraviolet A sunlamp induces 75% of cyclobutane pyrimidine dimers in human keratinocytes in vitro. Br J Dermatol 1999; 140(6), 1023-30.
  15. Toshiro, M., Saijo, M., Kuraoka, I., Kobayashi, T., Nakatsu, Y., Nagai, A., Enjoji, T., Masutani, C., Sugasawa, K., Hanaoka, F., Yasui, A., Tanaka, K. DNA Repair Protein XPA Binds Replication Protein A (RPA). J Biol Chem 1995; 270, 4152-4157.
  16. Woollons, A., Clingen, P.H., Price, M.L., Arlett, C.F., Green, M.H. Induction of mutagenic DNA damage in human fibroblasts after exposure to artificial tanning lamps. Br J Dermatol 1997; 137(5), 687-92.
  17. Baron, E.D., Fourtanier, A., Compan, D., Medaisko, C., Cooper, K.D., Stevens, S.R. High Ultraviolet a Protection Affords Greater Immune Protection Confirming that Ultraviolet A Contributes to Photoimmunosuppression in Humans. J Invest Dermatol 2003; 121, 869–875. doi:10.1046/j.1523- 1747.2003.12485.x.
  18. Ferguson, J., Brown, M., Alert, D., Bielfeldt, S., Brown, J., Chardon, A., Hourseau, C., Mazilier, C., Cuthbert, J., D’Arcy-Burt, K., Jolley, J., Murdoch, M., Finkel, P., Masson, P., Merot, F., Maclennan, A., Poret, J., Siladgi, S. Collaborative development of a sun protection factor test method: A proposed European standard. Int J Cosm Sci 1996; 18, 203–218.
  19. Bickers, D.R. Photosensitivity and other reactions to light. In Harrison’s Principles of Internal Medicine, 18th Edition; Mc-Graw Hill: New York, NY, 2005.
  20. Lam, M., Lee, Y., Deng, M., Hsia, A.H., Morrissey, K.A., Yan, C., Azzizudin, K., Oleinick, N.L., McCormick, T.S., Cooper, K.D., Baron, E.D. Photodynamic Therapy with the Silicon Phthalocyanine Pc 4 Induces Apoptosis in Mycosis Fungoides and Sezary. Adv Hematol 2010.
  21. Iordanou, E., Berneburg, M. Phototherapy and photochemotherapy. J Dtsch Dermatol Ges 2010; 8(7), 533-541.
  22. Hochberg, M.C., Silman, A.J., Smolen, J.S. Rheumatology, 5th edition.; Elsevier Health Sciences: Philadelphia, PA, 2010.
  23. Hirotsu, C., Rydlewski, M., Araújo, M.S., Tufik S., Andersen, M.L. Sleep Loss and Cytokines Levels in an Experimental Model of Psoriasis. PLoS One 2012, 7(11). doi: 10.1371/journal.pone.0051183.
  24. Li, W., Qureshi, A.A., Schernhammer, E.S., Han, J. Rotating night shift work and risk of psoriasis in US women. J Invest Dermatol 2013; 133(2), 565–567.
  25. Baron, E.D., Suggs, A. Introduction to Photobiology. Dermatol Clin 2014; 32(3), 255-66.
  26. de Lima-Bessa, K,M., Armelini, M.G., Chiganças, V., Jacysyn, J.F., Amarante- Mendes, G.P., Sarasin, A., Menck, C.F. CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells. DNA Repair 2008; 7(2), 303-12.
  27. Gaddameedhi, S., Selbya, C.P., Kaufmannb, W.K, Smarte, R.C, Sancar A. Control of skin cancer by the circadian rhythm. PNAS 2011; 108(46), 18790- 18795.
  28. Kang, T.; Reardon, J.T.; Sancar, A. Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein. Nucleic Acids Res 2011, 39(8), 3176–3187.
  29. Sugasawa, K. Xeroderma pigmentosum genes: functions inside and outside DNA repair. Carcinogensis 2008, 29(3), 455-465.
  30. Li, Z.; et al. UV-induced nuclear import of XPA is mediated by importin-α4 in an ATR-dependent manner. PloS One 2013, 8(7).

AUTHOR CORRESPONDENCE

Elma D. Baron MD…….................................... elma.baron@case.edu
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