Aesthetics

The Therapeutic Use of Antioxidants for Melasma

By August 25, 2020No Comments

Featured Article

Featured Article

With a well demonstrated impact on quality of life, melasma is a common cause for seeking dermatologic care. There is no universally efficacious therapy, so combination treatment is preferred. Therapies include topical hypopigmenting agents, laser treatment, microneedling, chemical peels, radiofrequency, and oral medications.1 Furthermore, it is critical for patients to avoid exacerbating factors.

Read more

In this review, authors discuss the well-defined role of oxidative stress in melasma and the therapeutic efficacy of various antioxidants for patients suffering from melasma, focusing on studies investigating the role of vitamin C, azelaic acid, cysteamine, glutathione, carotenoids, and numerous other antioxidants in disorders of hyperpigmentation.

Kayla M. Babbush BS, Remy A. Babbush BS, Amor Khachemoune MD FAAD FACMS

 

Melasma is a chronic and acquired skin disorder of hyperpigmentation that presents with symmetric hypermelanosis of sun exposed areas, especially the face. Disease prevalence, ranging from 1 to 50%, varies with gender, ethnicity, skin phenotype, and sun exposure.

The pathogenesis of melasma is incompletely understood, which poses a challenge for disease management. Causative factors include genetics, ultraviolet (UV) radiation, cosmetics, pregnancy, hormonal therapy, phototoxic drugs, and various medications.

Melasma is evaluated by Melasma Area and Severity Index (MASI) score, modified MASI (mMASI) score, Melasma Quality of Life Scale (MelasQoL), colorimetry, and mexametry.

With a well demonstrated impact on quality of life, melasma is a common cause for seeking dermatologic care. There is no universally efficacious therapy, so combination treatment is preferred. Therapies include topical hypopigmenting agents, laser treatment, microneedling, chemical peels, radiofrequency, and oral medications.1 Furthermore, it is critical for patients to avoid exacerbating factors.

The skin, a protective organ critical in homeostasis, is the site of numerous biochemical processes, including the generation of free radicals, namely reactive oxygen and nitrogen species. Reactive oxygen species (ROS) are necessary for biological signaling processes, but, in excess, ROS can damage biomolecules.3 There is clear evidence of oxidative stress in melasma.

Read Full Article Now
Article Cited in this Post

You May Also Like

JDD in the News: Acne Information on Instagram, CAL/BDP Cream Improves QoL

| Featured Articles, JDD Highlights, JDD Higlights, JDD in the Media, The Latest | No Comments
By Allison Sit HCP Live covered a March JDD study in its article, “Acne-Related Social Media Content Lacking Dermatologist Input.” The study, “Acne Information on Instagram: Quality of Content and…

Novel Biome-Care Technology of C. acnes subsp. defendens Demonstrates Health and Aesthetic Benefits for Facial Skin

| Featured Articles, JDD Highlights, JDD Webinars, Rosacea, The Latest, Webinars on Demand | No Comments
As one ages, changes to skin biology can result in a shift in the skin biome causing microbial imbalance (dysbiosis) and significant reductions in certain microbial populations that maintain skin…

JDD in the News: AI Perceptions, Platelet Count & Psoriasis

| Featured Articles, JDD Highlights, JDD Higlights, JDD in the Media, The Latest | No Comments
By Allison Sit Dermatology News, Dermatology Times and Practical Dermatology all wrote about the February JDD study, “Perceptions of Artificial Intelligence Integration into Dermatology Clinical Practice: A Cross-Sectional Survey Study.”…

Leave a Reply