From the Vault: Prospective single arm study reports sustained gains in firmness and hydration after cell free autologous injections
We pulled this article from the JDD vault. A prospective, single arm study of 21 women evaluated deep dermal to immediate subdermal micropuncture injections of cell free Blood Cell Secretome, also known as autologous conditioned serum, over 24 weeks. The primary outcome was skin elasticity by cutometry, with secondary assessments of safety, hydration, and global aesthetic improvement.
The authors report statistically significant increases in skin firmness at 12 weeks that continued through 24 weeks, concurrent reductions in skin tiring, improvements in hydration, and favorable aesthetic ratings. No treatment related adverse reactions were observed in this cohort. Preclinical rationale is noted, since BCS contains inflammation resolving cytokines and growth factors that may counteract age related reductions in TGF beta signaling and collagen synthesis.
These findings suggest cell free BCS may offer a novel, autologous approach to improve biomechanical and hydration measures associated with younger appearing skin. Limitations include the small sample size, single center and single arm design, and relatively short follow up.
Read the full JDD article for detailed methods, cutometry results, injection technique, and patient selection considerations.
J Drugs Dermatol. 2021;20(6):682-688. doi:10.36849/JDD.5018
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