- Hidaka T, Ogawa E, Kobayashi EH, et al. The aryl hydrocarbon receptor links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin. Nat Immunol. 2017;18(1):64-73.
- Haarmann-Stemmann T, Esser C, Krutmann J. The Janus-faced role of AhR signaling in the skin: consequences for prevention and treatment of skin disorders. J Invest Dermatol. 2015;135(11):2572-2576.
- Baek J-O, Cho J, Roh J-Y. Associations between ambient air pollution and medical care visits for atopic dermatitis. Environ Res. 2021;195:110153.
- Wang H, Sun J, Qian Z, et al. Association between air pollution and atopic dermatitis in Guangzhou, China: modification by age and season. Br J Dermatol. 2021;184(6):1068-1076.
- Khazaal AQ, Haque N, Krager CR, et al. Aryl hydrocarbon receptor affects circadian-regulated lipolysis through an E-Box-dependent mechanism. Mol Cell Endocrinol. 2023;559:111809.
- Yoshimatsu Y, Sujino T, Miyamoto K, et al. Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios+ Tregs in the gut. Cell Rep. 2022;39(6):110773.
- Han SG, Han S-S, Toborek M, Hennig B. EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes. Toxicol Appl Pharmacol. 2012;261(2):181- 188.
- Niestroy J, Barbara A, Herbst K, et al. Single and concerted effects of benzo [a] pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. Toxicol In Vitro. 2011;25(3):671-683.
- Tsuji G, Takahara M, Uchi H, et al. Identification of ketoconazole as an AhR-Nrf2 activator in cultured human keratinocytes. J Invest Dermatol. 2012;132(1):59-68.
- Fernández-Gallego N, Sánchez-Madrid F, Cibrian D. Role of AHR ligands in skin homeostasis and cutaneous inflammation. Cells. 2021;10(11):3176.
- Haas K, Weighardt H, Deenen R, et al. Aryl hydrocarbon receptor in keratinocytes is essential for murine skin barrier integrity. J Invest Dermatol. 2016;136(11):2260-2269.
- Esser C, Bargen I, Weighardt H, et al. Functions of the aryl hydrocarbon receptor in the skin. Semin Immunopathol. 2013;35(6):677-691.
- Furue M, Hashimoto-Hachiya A, Tsuji G. Aryl hydrocarbon receptor in atopic dermatitis and psoriasis. Int J Mol Sci. 2019;20(21):5424.
- Riaz F, Pan F, Wei P. Aryl hydrocarbon receptor: The master regulator of immune responses in allergic diseases. Front Immunol. 2022;13:1057555.
- Furue M. Regulation of filaggrin, loricrin, and involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: pathogenic implications in atopic dermatitis. Int J Mol Sci. 2020;21(15):5382.
- Quintana FJ, Sherr DH. Aryl hydrocarbon receptor control of adaptive immunity. Pharmacol Rev. 2013;65(4):1148-1161.
- Li S, Bostick JW, Zhou L. Regulation of innate lymphoid cells by AhR. Front Immunol. 2018;8:1909.
- Sutter CH, Olesen KM, Bhuju J, et al. AHR regulates metabolic reprogramming to promote SIRT1-dependent keratinocyte differentiation. J Invest Dermatol. 2019;139(4):818-826.
- Furue M, Uchi H, Mitoma C, et al. Antioxidants for healthy skin: the emerging role of AhR and nuclear factor-erythroid 2-related factor-2. Nutrients. 2017;9(3):223.
- Furue M, Ulzii D, Vu Y, et al. Pathogenesis of atopic dermatitis: Current paradigm. Iran J Immunol. 2019;16(2):97-107.
- Yao Y, Ravn Jørgensen A-H, Thomsen SF. Biologics for chronic inflammatory skin diseases: an update for the clinician. J Dermatolog Treat. 2020;31(2):108- 130.
- Chiesa Fuxench ZC, Block JK, Boguniewicz M, et al. Atopic Dermatitis in America study. J Invest Dermatol. 2019;139(3):583-590.
- Silverberg JI, Simpson EL. Association between severe eczema in children and multiple comorbid conditions and increased healthcare utilization. Pediatr Allergy Immunol. 2013;24(5):476-486.
- Eichenfield LF, Tom WL, Chamlin SL, et al. Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol. 2014;70(2):338-351.
- Yasir M, Goyal A, Sonthalia S. Corticosteroid Adverse Effects. StatPearls. Treasure Island (FL); StatPearls Publishing; 2023.
- Ference JD, Last AR. Choosing topical corticosteroids. Am Fam Physician. 2009;79(2):135-140.
- Puar N, Chovatiya R, Paller AS. New treatments in atopic dermatitis. Ann Allergy Asthma Immunol. 2021;126(1):21-31.
- Løset M, Brown SJ, Saunes M, Hveem K. Genetics of atopic dermatitis. Dermatology. 2019;235(5):355-364.
- Palmer CN, Irvine AD, Terron-Kwiatkowski A, et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet. 2006;38(4):441-446.
- Irvine AD, McLean WI, Leung DY. Filaggrin mutations associated with skin and allergic diseases. N Engl J Med. 2011;365(14):1315-1327.
- Ji H, Li X-K. Oxidative stress in atopic dermatitis. Oxid Med Cell Longev. 2016;2016:2721469.
- Ständer S. Atopic dermatitis. N Engl J Med. 2021;384(12):1136-1143.
- Kim J, Han Y, Ahn J, et al. Airborne formaldehyde causes skin barrier dysfunction in atopic dermatitis. Br J Dermatol. 2016;175(2):357-363.
- Wang C, Wei C-C, Wan L, et al. Association of exposure to hydrocarbon air pollution with the incidence of atopic dermatitis in children. Ital J Pediatr. 2021;47:1-9.
- Nakajima S, Tie D, Nomura T, Kabashima K. Novel pathogenesis of atopic dermatitis from the view of cytokines in mice and humans. Cytokine. 2021;148:155664.
- Chiricozzi A, Maurelli M, Peris K, Girolomoni G. Targeting IL-4 for the treatment of atopic dermatitis. Immunotargets Ther. 2020:151-156.
- Yamanaka K-i, Mizutani H. The role of cytokines/chemokines in the pathogenesis of atopic dermatitis. Curr Probl Dermatol. 2011;41:80-92.
- Zhang Y, Jing D, Cheng J, et al. The efficacy and safety of IL-13 inhibitors in atopic dermatitis. Front Immunol. 2022;13:923362.
- Lebwohl MG, Stein Gold L, Strober B, et al. Phase 3 trials of tapinarof cream for plaque psoriasis. N Engl J Med. 2021;385(24):2219-2229.
- Strober B, Gold LS, Bissonnette R, et al. One-year safety and efficacy of tapinarof cream for the treatment of plaque psoriasis: Results from the PSOARING 3 trial. J Am Acad Dermatol. 2022;87(4):800-806.
- Mooney N, Teague J, Gehad A, et al. Tapinarof inhibits the formation, cytokine production, and persistence of resident memory T cells in vitro. Society For Investigative Dermatology, May 18–21, 2022.
- Zaid A, Mackay LK, Rahimpour A, et al. Persistence of skin-resident memory T cells within an epidermal niche. Proc Natl Acad Sci. 2014;111(14):5307- 5312.
- Stein Gold L, Lebwohl MG, Brown PM, et al. Tapinarof cream 1% once daily for plaque psoriasis in two pivotal phase 3 trials: Minimal systemic exposure is consistent with adverse event profile. American Academy of Dermatology Conference, March 17-21, 2023.
- Jett JE, McLaughlin M, Lee MS, et al. Tapinarof cream 1% for extensive plaque psoriasis: a maximal use trial on safety, tolerability, and pharmacokinetics. Am J Clin Dermatol. 2022;23(1):83-91.
- Paller A, Jett JE, Hebert AA, et al. Tapinarof cream 1% once daily for the treatment of extensive atopic dermatitis in adolescents and children: outcomes from the 4-week maximal usage trial. Annual Revolutionizing Atopic Dermatitis Conference, April 29-May 1, 2023.
- Dermavant Sciences. Press Release. May 16, 2023. Available at: https:// tinyurl.com/hx46twey. Accessed August 11, 2023.
AUTHOR CORRESPONDENCE
Lawrence F. Eichenfield MD leichenfield@rchsd.org